Rec8 Inhibitors
Rec8 inhibitors, in a broad sense, consist of chemicals that can interfere with the process of cell division, especially the separation of sister chromatids, a process where Rec8 plays a crucial role. Nocodazole, Paclitaxel, Colchicine, Vinblastine, Vincristine, and Griseofulvin all disrupt microtubule dynamics, which are essential for pulling sister chromatids apart during cell division. By disrupting microtubule dynamics, these chemicals can indirectly affect the function of Rec8.
On the other hand, Etoposide, ICRF-193, ICRF-159, Merbarone, Teniposide, and Amsacrine all inhibit topoisomerase II, an enzyme required for the separation of sister chromatids. By inhibiting topoisomerase II, these chemicals can indirectly affect the function of Rec8, which is necessary for keeping sister chromatids together until their separation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which can indirectly affect Rec8 by disrupting the physical separation of sister chromatids. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their disassembly, which can indirectly affect Rec8 by disrupting the physical separation of sister chromatids. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, which can indirectly affect Rec8. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
Vinblastine binds to tubulin, inhibiting its polymerization into microtubules, which can indirectly affect Rec8. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule dynamics, which can indirectly affect Rec8. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, which is required for the separation of sister chromatids and can indirectly affect Rec8. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $330.00 $898.00 | 7 | |
ICRF-193 is a bisdioxopiperazine compound that inhibits topoisomerase II, indirectly affecting Rec8. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Teniposide inhibits topoisomerase II, which is required for the separation of sister chromatids and can indirectly affect Rec8. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is an inhibitor of topoisomerase II, indirectly affecting Rec8. | ||||||