RCL1 Inhibitors
RCL1 inhibitors are a class of chemical compounds that specifically target and inhibit the function of RCL1, a critical protein involved in the maturation of ribosomal RNA (rRNA) during ribosome biogenesis. RCL1 plays a pivotal role in the processing of pre-rRNA, particularly in the formation of the small ribosomal subunit. Ribosomes are essential cellular structures responsible for protein synthesis, and their assembly requires precise and coordinated steps in which RCL1 is a key participant. By facilitating the cleavage and processing of the 18S rRNA, RCL1 ensures the proper assembly and function of the small ribosomal subunit, which is crucial for the translation of mRNA into proteins. Inhibitors of RCL1 function by binding to specific sites on the protein, blocking its ability to interact with pre-rRNA or other components involved in ribosome biogenesis, ultimately disrupting the production of functional ribosomes.
The inhibition of RCL1 can have far-reaching effects on cellular processes that rely on efficient protein synthesis. By impairing the assembly of the small ribosomal subunit, RCL1 inhibitors reduce the cell's capacity to produce proteins, leading to disruptions in growth, replication, and overall cellular function. Researchers use RCL1 inhibitors to study the complex pathways involved in ribosome biogenesis, providing insights into the precise mechanisms by which ribosomal RNA is processed and assembled into functional ribosomes. These inhibitors are also valuable tools for exploring the regulation of ribosome production, helping to uncover the intricate network of proteins and processes that maintain the balance between ribosome synthesis and cellular demands. Through the study of RCL1 inhibitors, scientists can gain a deeper understanding of ribosomal assembly, RNA processing, and the broader implications of ribosome biogenesis in cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor known to suppress various protein kinases. By inhibiting these kinases, it can decrease phosphorylation events that may be crucial for the activity and regulation of RCL1, potentially leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinases (PI3K) inhibitor. PI3K signaling is critical for many cellular functions. Inhibition of this pathway can reduce the phosphorylation state of proteins downstream, which may include RCL1, thereby decreasing its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor. By inhibiting mTOR, it can interrupt protein synthesis and other regulatory functions, which could indirectly inhibit the functional activity of RCL1 by altering the cellular environment in which RCL1 operates. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase (CDK) inhibitor. CDKs play a role in cell cycle progression and transcriptional regulation. Inhibition could alter the cell cycle status and indirectly affect RCL1's functional activity due to changes in the cellular proliferation context. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An MEK inhibitor which impairs the MAPK/ERK pathway. This pathway is involved in cell proliferation and differentiation, which could indirectly affect RCL1's functional activity by altering the cellular growth signals. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor, which operates similarly to U0126, potentially leading to a decrease in RCL1 activity by impacting the same MAPK/ERK signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor. By inhibiting JNK, it affects the JNK signaling pathway involved in stress responses, potentially leading to an indirect decrease in RCL1 functional activity due to altered cellular stress responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor. The p38 MAPK pathway is implicated in inflammatory responses and apoptosis. Inhibiting this pathway could lead to indirect functional inhibition of RCL1 by altering the cellular response to stress and inflammation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, which could lead to a decrease in RCL1 activity similarly to LY294002 by targeting the PI3K signaling pathway. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
A protein kinase C (PKC) inhibitor. PKC is involved in various signaling pathways, including those that regulate the cell cycle and transcription. Inhibition of PKC could indirectly inhibit RCL1 by affecting these regulatory pathways. | ||||||