RBM47 Activators
Activators within the RBM47 domain are chemical entities that interface with transcriptional and post-transcriptional regulatory mechanisms, indirectly enhancing the function or expression of RNA-binding motif protein 47 (RBM47). RBM47 is implicated in RNA metabolism, including RNA splicing, stabilization, and processing. Agents like 5-Azacytidine act at the level of nucleic acid synthesis and processing, where they can alter the RNA landscape, presumably necessitating the compensatory upregulation of RNA-binding proteins such as RBM47 to maintain RNA homeostasis. Similarly, transcriptional like α-Amanitin and DRB could indirectly necessitate the heightened activity of RBM47 to stabilize existing RNA pools, given their role in diminishing RNA polymerase activity. Furthermore, chromatin-modifying agents like Trichostatin A and Sodium Butyrate alter the epigenetic landscape, resulting in the increased transcription of genes involved in RNA binding and processing, including that of RBM47.
Other compounds in this classification, such as Brefeldin A and Leptomycin B, exert their influence by perturbing intracellular trafficking and nuclear export, respectively. These disruptions can cause a cascade of cellular responses that include the upregulation or altered distribution of RNA-binding proteins to ensure efficient RNA metabolism. Compounds like Cycloheximide and Puromycin, which interfere with the process of translation, might indirectly provoke a cellular response where mRNA-stabilizing factors like RBM47 become more pivotal.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into RNA, potentially altering RNA splicing and affecting proteins like RBM47 which are involved in RNA processing and stability. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disruptor of Golgi apparatus structure, which can lead to altered RNA trafficking and might increase the need for RNA-binding proteins like RBM47 for RNA stabilization and processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibitor of RNA polymerase II, leading to decreased RNA transcription and potentially upregulating RNA-binding proteins like RBM47 to stabilize existing RNA transcripts. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor which leads to changes in chromatin structure and can enhance the expression of genes encoding RNA-binding proteins like RBM47. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibitor of RNA polymerase II phosphorylation, altering RNA processing and potentially increasing the cellular reliance on RNA-binding proteins such as RBM47. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Inhibitor of CRM1/exportin 1 that blocks nuclear export, possibly leading to accumulation of RNA-binding proteins like RBM47 in the nucleus, where they are active. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Antitumor antibiotic that binds to G-C rich DNA sequences, possibly upregulating RNA-binding proteins such as RBM47 to counteract the effects on transcription. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Causes premature chain termination during protein synthesis; this stress may upregulate RNA-binding proteins like RBM47 to stabilize mRNAs. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can cause hyperacetylation of histones, potentially leading to enhanced transcription and subsequent stabilization of mRNA by RBM47. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Cyclin-dependent kinase inhibitor that affects transcription regulation, potentially leading to an increased role for RNA-binding proteins like RBM47 in mRNA processing. | ||||||