RBM17 Inhibitors
RBM17 inhibitors are chemical compounds that modulate the activity of RBM17, which stands for RNA-binding motif protein 17. RBM17 is a multifunctional RNA-binding protein involved in various aspects of RNA metabolism, including pre-mRNA splicing, mRNA stability, and alternative splicing regulation. The protein contains multiple RNA-binding domains and is crucial for ensuring the fidelity and proper processing of RNA molecules within the cell.
RBM17 inhibitors exert their effects by interfering with the RNA-binding capacity of RBM17 or by modulating its interactions with other RNA-processing factors. This interference can lead to disruptions in RNA splicing patterns, mRNA stability, and alternative splicing events, ultimately influencing the transcriptome and proteome of the cell. Researchers employ RBM17 inhibitors as invaluable tools to investigate the intricate mechanisms of RNA processing and the role of RBM17 in shaping the post-transcriptional landscape. Understanding the functions and regulatory pathways associated with RBM17 is pivotal in unraveling the complexities of gene expression and RNA biology, and RBM17 inhibitors serve as crucial assets in advancing our knowledge in this field.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
A compound that intercalates into DNA, inhibiting transcription and potentially reducing RBM17 expression as part of a broader impact on gene expression. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
A splicing inhibitor that could affect RBM17 levels by disrupting splicing machinery, where RBM17 is a component. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
A biflavonoid that inhibits splicing, possibly leading to reduced RBM17 expression by generally affecting splicing factors. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
A splicing inhibitor that could disrupt the splicing process and indirectly affect the expression of proteins such as RBM17. | ||||||
Herbimycin A | 70563-58-5 | sc-3516 sc-3516A | 100 µg 1 mg | $277.00 $1532.00 | 13 | |
A benzoquinoid ansamycin that has been shown to inhibit heat shock protein 90 (HSP90), potentially affecting RBM17 expression indirectly. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that inhibits transcription and might lower RBM17 levels by broadly suppressing gene expression. | ||||||
Cdc2-Like Kinase Inhibitor, TG003 | 300801-52-9 | sc-202528 sc-202528A | 5 mg 25 mg | $139.00 $548.00 | 6 | |
A kinase inhibitor that targets Clk/Sty kinases, which are involved in splicing regulation, potentially affecting RBM17 expression. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
A eukaryotic translation initiation inhibitor that could reduce RBM17 protein levels by inhibiting translation. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
It inhibits protein synthesis at the initial elongation step, which could lead to decreased levels of proteins, including RBM17. | ||||||