RBM11 Activators
RBM11, standing for RNA Binding Motif Protein 11, is a gene that encodes a protein implicated in the intricate web of RNA processing and regulation. As a member of the RNA-binding protein family, RBM11 is thought to play a role in post-transcriptional modification, influencing the fate of RNA after it has been transcribed from DNA. The protein's exact functions, interactions, and regulatory mechanisms are the subject of ongoing research, but it is clear that RBM11 is one of many players in the cell's complex symphony of gene expression. The expression of RBM11 itself is subject to regulation by various biological signals and pathways, with certain chemicals having the potential to serve as inducers, upregulating the transcription of the RBM11 gene, thus increasing the production of the RBM11 protein.
Exploring the landscape of chemical activators that might induce RBM11 expression unveils a spectrum of small molecules and biochemical agents capable of interacting with cellular machinery. These activators range from naturally occurring compounds, like retinoic acid, which can engage nuclear receptors and initiate transcriptional cascades, to synthetic molecules like 5-Azacytidine, which may alter epigenetic marks and unlock silenced genes. Other substances, like forskolin, might raise the levels of secondary messengers such as cAMP, potentially leading to the activation of protein kinases that target transcription factors directly involved in the upregulation of RBM11. Epigenetic modulators such as Trichostatin A or Sodium butyrate may remodel chromatin architecture, rendering the RBM11 gene more accessible for transcriptional machinery. The diversity of these chemicals underscores the multifaceted nature of gene expression regulation, reflecting the array of molecular pathways that converge on the control of a single gene like RBM11. Each activator operates via a distinct mechanism, contributing to the potential elevation of RBM11 expression through a unique interplay with cellular components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could upregulate RBM11 by catalyzing cAMP synthesis, which might then trigger a cascade of events leading to the activation of CREB, a transcription factor that could enhance RBM11 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might stimulate RBM11 expression by interacting with its nuclear receptors, which bind to specific response elements in the RBM11 promoter, prompting transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a cytidine analog, 5-Azacytidine could induce the expression of RBM11 by incorporating into RNA and DNA, thereby disrupting methylation patterns and facilitating the transcription of previously silenced genes, including potentially RBM11. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may promote RBM11 expression by specifically inhibiting histone deacetylase enzymes, leading to an accumulation of acetylated histones, which are associated with active transcription, near the RBM11 gene locus. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could elevate RBM11 expression levels by activating glucocorticoid receptors, which may bind to glucocorticoid response elements upstream of the RBM11 coding region, initiating its transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may increase RBM11 transcription by binding estrogen receptors that interact with estrogen response elements on the RBM11 gene, driving its transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate could upregulate RBM11 by activating Nrf2 signaling, a pathway known for its role in responding to oxidative stress, which may include the upregulation of protective genes like RBM11. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA could stimulate RBM11 gene transcription by acting as a direct activator of PKC, which in turn may lead to the activation of downstream transcription factors that drive RBM11 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate could lead to an increase in RBM11 expression by inhibiting histone deacetylases, thereby maintaining a hyperacetylated state of chromatin that is conducive to gene expression at the RBM11 locus. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin might induce RBM11 by disrupting calcium homeostasis within the endoplasmic reticulum, triggering a signaling response that culminates in the activation of transcription factors responsible for RBM11 synthesis. | ||||||