RAI16 Activators
RAI16, or Retinoic Acid Induced 16, is a gene of intrigue in the realm of molecular biology with a protein product that is thought to play a role in intracellular signaling and transcriptional regulation. The protein is aptly named for its discovery as a retinoic acid-responsive gene, suggesting that its expression can be upregulated in the presence of certain chemical stimuli. RAI16's exact function remains an area of active research, but it is speculated that the protein could be involved in fundamental cellular processes. As such, understanding the compounds that can influence the expression of RAI16 provides valuable insights into the modulation of gene expression and the intricate web of intracellular communication.
A diverse array of chemical compounds has been identified that can potentially induce the expression of the RAI16 protein, showcasing the variety of molecular pathways that intersect at the regulation of this gene. All-trans Retinoic Acid, a metabolite of Vitamin A, is a well-known inducer of gene expression through its interaction with nuclear receptors that bind directly to DNA, altering gene transcription. Similarly, compounds like 1,25-Dihydroxyvitamin D3 and Beta-estradiol operate through their respective hormone receptors to orchestrate changes in gene expression patterns, including the upregulation of RAI16. Forskolin, another activator, works through the elevation of cAMP, a secondary messenger that influences a plethora of biological processes including the transcription of certain genes. Compounds such as Sodium Butyrate act epigenetically to open up chromatin structure, thereby facilitating increased gene expression. In addition, naturally occurring molecules like Epigallocatechin gallate (EGCG) from green tea and Curcumin from turmeric are known for their ability to interact with cellular signaling pathways, potentially leading to an increase in RAI16 expression. These diverse mechanisms underscore the complexity of gene regulation and highlight the intricate network of signals that control protein expression within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
This vitamin A derivative initiates transcription by binding to retinoic acid receptors, which may specifically upregulate RAI16 expression as part of cellular differentiation processes. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
The hormonally active form of vitamin D binds to its nuclear receptor, potentially stimulating RAI16 expression in a pathway related to immune response or calcium absorption. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a potent estrogen, β-Estradiol could enhance RAI16 expression by engaging with estrogen receptors, prompting transcriptional changes in reproductive tissues or bone. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating intracellular cAMP levels, forskolin can activate transcription factors such as CREB, which may specifically target RAI16 gene promoter regions to increase expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
This diester activates PKC, triggering a signaling cascade that can lead to the transcriptional upregulation of genes like RAI16 by altering the activity of transcription factors. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a catechin in green tea, may exert a stimulatory effect on RAI16 expression through antioxidant response pathways or by interacting with cellular kinases. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This compound can promote acetylation of histones, leading to an open chromatin structure and potentially enhancing the transcriptional activation of RAI16 in certain cell types. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, lithium chloride can stimulate the Wnt signaling pathway, possibly leading to an upsurge in RAI16 expression through changes in gene transcription dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As an activator of sirtuins and a modulator of several signaling pathways, resveratrol may specifically induce the expression of RAI16 through epigenetic alterations or sirtuin-mediated transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid interacts with glucocorticoid receptors to elicit a transcriptional response, which could include the upregulation of RAI16 expression in response to stress or metabolic changes. | ||||||