RAGE Activators
RAGE activators are primarily chemicals that contribute to the formation of advanced glycosylation end products (AGEs), which are the principal ligands for RAGE activation. Acetaldehyde, Glyoxal, and Formaldehyde are aldehydes that interact with proteins to form AGEs. These AGEs can bind to RAGE and activate downstream signaling pathways, including those involving inflammation and cellular stress. Similarly, Methylglyoxal and 4-Hydroxynonenal are reactive carbonyl species that undergo reactions to form AGEs, thereby activating RAGE. Acrolein, another reactive aldehyde, also produces AGEs that interact with RAGE.
In the case of sugars like Glucose, Fructose, Ribose, Threose, and Galactose, these carbohydrates can form AGEs through non-enzymatic glycation of proteins. This leads to the formation of AGEs that subsequently bind to and activate RAGE. Ascorbic Acid, though generally an antioxidant, can paradoxically induce glycation under certain conditions. This forms AGEs that can interact with RAGE, again activating downstream pathways. In summary, these chemicals either directly or indirectly result in the formation of AGEs, the primary activators of RAGE.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glyoxal, 40 % Solution | 107-22-2 | sc-285868 sc-285868A | 25 ml 50 ml | $89.00 $119.00 | 1 | |
Another AGE precursor that binds proteins to activate RAGE. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
Forms crosslinks with proteins leading to AGEs that activate RAGE. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $146.00 $437.00 $478.00 $754.00 $1446.00 | 3 | |
Reactive dicarbonyl compound that forms AGEs to activate RAGE. | ||||||
Valeramide | 626-97-1 | sc-280175 | 5 g | $62.00 | ||
Forms lipid-derived AGEs that activate RAGE. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Elevated levels lead to AGE formation and subsequent RAGE activation. | ||||||
D-(−)-Fructose | 57-48-7 | sc-221456 sc-221456A sc-221456B | 100 g 500 g 5 kg | $41.00 $91.00 $166.00 | 3 | |
Like glucose, leads to AGEs that activate RAGE when present in high levels. | ||||||
D-(−)-Ribose | 50-69-1 | sc-221458 sc-221458A sc-221458B sc-221458C sc-221458D sc-221458E sc-221458F | 5 g 25 g 100 g 250 g 1 kg 5 kg 10 kg | $26.00 $58.00 $112.00 $235.00 $612.00 $1224.00 $2040.00 | 1 | |
Forms AGEs rapidly, leading to RAGE activation. | ||||||
D-(−)-Threose | 95-43-2 | sc-214795 | 50 mg | $73.00 | ||
Rapidly produces AGEs which can activate RAGE. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Can induce glycation of proteins, leading to AGEs that activate RAGE. | ||||||
D-Galactose | 59-23-4 | sc-202564 | 100 g | $288.00 | 4 | |
Forms glycation end products, contributing to RAGE activation. | ||||||