Methylglyoxal solution (CAS 78-98-8)
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Methylglyoxal, often presented as a solution for laboratory use, is a highly reactive alpha-ketoaldehyde compound derived primarily through the degradation of glucose via different metabolic pathways, including the glycolysis pathway. Its role in research is pivotal, particularly in the study of advanced glycation end products (AGEs) and their implications in various biochemical processes. Methylglyoxal serves as a critical reagent in elucidating the pathways of non-enzymatic glycation, which can lead to a better understanding of cellular aging and dysfunction. Its high reactivity also makes it useful in synthetic chemistry, where it is used to modify nucleic acids and proteins, thereby facilitating the exploration of molecular structures and functions. Moreover, methylglyoxal is employed in environmental science studies to assess its impact and behavior in biological systems, contributing to our understanding of organic compound transformations in nature.
Methylglyoxal solution (CAS 78-98-8) References
- Cross-linking of proteins by Maillard processes: characterization and detection of lysine-arginine cross-links derived from glyoxal and methylglyoxal. | Lederer, MO. and Klaiber, RG. 1999. Bioorg Med Chem. 7: 2499-507. PMID: 10632059
- Chemiluminescence derivatization of methylglyoxal using 2-aminonicotinic acid. | Ohba, Y., et al. 2000. Chem Pharm Bull (Tokyo). 48: 1236-8. PMID: 10959598
- In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine. | Ghosh, M., et al. 2006. Toxicol Appl Pharmacol. 212: 45-58. PMID: 16112157
- Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide. | Nakayama, M., et al. 2007. Redox Rep. 12: 125-33. PMID: 17623519
- Toxic concentrations of exogenously supplied methylglyoxal in hybridoma cell culture. | Roy, BM., et al. 2004. Cytotechnology. 46: 97-107. PMID: 19003265
- Secondary organic aerosol formation by self-reactions of methylglyoxal and glyoxal in evaporating droplets. | De Haan, DO., et al. 2009. Environ Sci Technol. 43: 8184-90. PMID: 19924942
- A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations: the N-acetyl-L-cysteine assay. | Wild, R., et al. 2012. Anal Bioanal Chem. 403: 2577-81. PMID: 22580513
- Electrochemical determination of methylglyoxal as a biomarker in human plasma. | Chatterjee, S., et al. 2013. Biosens Bioelectron. 42: 349-54. PMID: 23208109
- Infrared spectroscopy as a rapid tool to detect methylglyoxal and antibacterial activity in Australian honeys. | Sultanbawa, Y., et al. 2015. Food Chem. 172: 207-12. PMID: 25442544
- Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels. | Huang, Q., et al. 2016. Metabolism. 65: 463-74. PMID: 26975538
- Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals. | Chu, JM., et al. 2016. Metab Brain Dis. 31: 1055-64. PMID: 27250968
- Electronic properties of some protein--methylglyoxal complexes. | Bone, S., et al. 1978. Proc Natl Acad Sci U S A. 75: 315-8. PMID: 272648
- Interaction of 2-keto-3-deoxyglucose with thiol- and amino-groups. | Jellum, E. 1968. Acta Chem Scand. 22: 1722-8. PMID: 5720620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methylglyoxal solution, 25 ml | sc-250394 | 25 ml | $143.00 | |||
Methylglyoxal solution, 100 ml | sc-250394A | 100 ml | $428.00 | |||
Methylglyoxal solution, 250 ml | sc-250394B | 250 ml | $469.00 | |||
Methylglyoxal solution, 500 ml | sc-250394C | 500 ml | $739.00 | |||
Methylglyoxal solution, 1 L | sc-250394D | 1 L | $1418.00 |