RAG1AP1 Inhibitors
RAG1AP1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the RAG1AP1 (Recombination Activating Gene 1 Activating Protein 1) protein. RAG1AP1 is a regulatory protein that interacts with the RAG1/RAG2 complex, which plays a pivotal role in the V(D)J recombination process. V(D)J recombination is crucial for generating diversity in the antigen receptors of the immune system, such as B-cell receptors and T-cell receptors. RAG1AP1 is thought to influence this recombination process by stabilizing or modulating the activity of the RAG1/RAG2 complex, thereby affecting the ability of immune cells to rearrange specific gene segments and produce a wide variety of antigen receptors. Inhibitors of RAG1AP1 work by binding to critical domains of the protein, interfering with its interaction with RAG1 or its regulatory role in the recombination process, which ultimately impacts the assembly and diversification of immune receptors.
The inhibition of RAG1AP1 leads to a disruption of the V(D)J recombination process, which affects the generation of diverse antigen receptor repertoires in immune cells. By blocking the interaction between RAG1AP1 and the RAG complex, these inhibitors hinder the precision and efficiency of gene rearrangement, which can lead to alterations in cellular functions related to the immune response. Researchers use RAG1AP1 inhibitors to study the precise role of this protein in the immune system's development and to understand how its regulation influences recombination events. These inhibitors are also valuable tools for exploring the broader mechanisms of V(D)J recombination and how proteins like RAG1AP1 contribute to maintaining the diversity and adaptability of the immune system. Additionally, studying RAG1AP1 inhibitors provides deeper insights into the complex network of regulatory proteins involved in the generation of antigen receptor diversity, helping to further our understanding of how immune cells are equipped to recognize and respond to a wide array of pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can inhibit protein kinases which are essential for the phosphorylation necessary for RAG1-activating protein 1 activation and function, thus leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinases (PI3K), which are involved in signaling pathways that RAG1-activating protein 1 participates in, resulting in the inhibition of RAG1-activating protein 1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a potent inhibitor of PI3K, and by inhibiting this kinase, it disrupts signaling pathways that are necessary for RAG1-activating protein 1 activity, thus inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase in cell growth and proliferation that intersects with pathways involving RAG1-activating protein 1, leading to inhibition of RAG1-activating protein 1-mediated processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 inhibits MEK, which is upstream of ERK in the MAPK pathway, a pathway where RAG1-activating protein 1 is active, thus inhibiting RAG1-activating protein 1 function through this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 selectively inhibits MEK1/2, which are crucial for the MAPK/ERK pathway, thereby inhibiting the signaling events that are essential for RAG1-activating protein 1 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of a signaling pathway that RAG1-activating protein 1 is involved in, and its inhibition results in reduced RAG1-activating protein 1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 inhibits p38 MAP kinase, which is involved in stress responses and is a pathway where RAG1-activating protein 1 functions, thereby inhibiting RAG1-activating protein 1 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP 2 inhibits Src family kinases, which participate in signaling pathways that are necessary for the full activity of RAG1-activating protein 1, leading to its inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor, and by inhibiting these kinases, it disrupts the signaling required for RAG1-activating protein 1 function, resulting in its inhibition. | ||||||