Rag B Inhibitors
Rag B is involved in the amino acid-mediated activation of mTORC1, a central component of cellular growth and metabolism. The above-mentioned compounds do not inhibit Rag B directly but affect the signaling pathways that Rag B is part of. They include inhibitors of mTOR itself, activators of AMPK, and other compounds that modulate cellular energy status and nutrient sensing pathways that converge on mTORC1.
The chemical class of indirect Rag B inhibitors includes agents that target various aspects of the mTOR pathway, either upstream or downstream of Rag B. These compounds can affect the activity of mTORC1 by changing the activation state of upstream kinases, altering the availability of cellular energy, or by directly inhibiting mTORC1 and mTORC2 complexes. They work by modulating the signaling network that controls cell growth and metabolism, which are processes that are critically dependent on the function of Rag B in amino acid sensing.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
A macrolide compound that forms a complex with FKBP12 and inhibits mTORC1, which Rag B regulates. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
An activator of AMPK that indirectly inhibits mTORC1 activity upstream of Rag B. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
A selective mTOR kinase inhibitor that affects mTORC1 and mTORC2 downstream of Rag B activity. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
A potent and selective mTOR inhibitor that acts downstream of Rag B. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
An HIV protease inhibitor that has been shown to inhibit the mTOR pathway, potentially affecting Rag B. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
An inhibitor of carnitine palmitoyltransferase-1 (CPT1) that might affect mTORC1 signaling and thereby influence Rag B function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can attenuate mTORC1 signaling upstream of Rag B. | ||||||
WYE-354 | 1062169-56-5 | sc-364652 sc-364652A | 10 mg 50 mg | $286.00 $1200.00 | ||
A selective inhibitor of mTOR that might suppress mTORC1 signaling downstream of Rag B. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
An anthelmintic compound that can uncouple mitochondrial oxidative phosphorylation, potentially altering cellular energy status and mTORC1 activity related to Rag B. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that activates SIRT1 and may have indirect effects on mTORC1 signaling related to Rag B. | ||||||