Rab 3A Inhibitors
Rab 3A inhibitors constitute a diverse array of compounds designed to modulate the function of the small GTPase Rab3A, crucial for regulated exocytosis and vesicle trafficking. Direct inhibitors like SecinH3 and Deltarasin directly target Rab3A, disrupting its membrane association and inhibiting its role in vesicle transport. These compounds act by specifically impeding the localization and activity of Rab3A, providing precise tools for investigating the cellular processes dependent on Rab3A. Indirect inhibitors, such as ML141, CC-223, and Latrunculin A, modulate Rab3A function indirectly by targeting key regulators like Cdc42, mTOR, and actin polymerization. The disruption of these regulators impacts the cellular events involving Rab3A, offering indirect means to inhibit Rab3A-mediated functions, particularly in regulated exocytosis. The inhibitors YM-254890, EHT1864, and NSC23766 indirectly influence Rab3A by targeting signaling pathways involving Gq/11, Rac GTPases, and ROCK, respectively, providing additional avenues for modulating Rab3A function.
CK666 and CK869, inhibitors of the actin-related protein 2/3 (Arp2/3) complex, indirectly affect Rab3A by disrupting actin polymerization. These compounds offer indirect means to inhibit Rab3A-dependent functions, particularly in regulated exocytosis, by modulating the cytoskeletal dynamics crucial for vesicle trafficking. In summary, the diverse Rab 3A inhibitors presented here provide researchers with valuable tools to dissect the intricate mechanisms governing Rab3A function and its involvement in various cellular processes. The direct and indirect modulation of Rab3A allows for nuanced investigations into its role in regulated exocytosis and vesicle trafficking, contributing to a deeper understanding of cellular dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 is a selective inhibitor of the small GTPase Rab3A, directly targeting its activity. By interfering with the prenylation process, SecinH3 disrupts the proper membrane association of Rab3A, inhibiting its function in vesicle trafficking. This compound acts as a direct inhibitor by specifically impeding the localization and activity of Rab3A, crucial for regulated exocytosis in various cellular processes. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective Cdc42 inhibitor that indirectly influences Rab3A. By targeting Cdc42, a regulator of cytoskeletal dynamics, ML141 modulates vesicle trafficking indirectly. The disruption of Cdc42 activity impacts the cellular processes involving Rab3A, such as vesicle transport and exocytosis, providing an indirect means to inhibit Rab3A-mediated functions. | ||||||
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid | 314042-01-8 | sc-503400 | 10 mg | $300.00 | ||
CID-1067700 is a small molecule inhibitor of ARF6, indirectly affecting Rab3A. By inhibiting ARF6, a small GTPase involved in endocytic processes, CID-1067700 modulates vesicle trafficking indirectly. The disruption of ARF6 activity impacts cellular events associated with Rab3A, providing an indirect means to inhibit Rab3A-mediated functions, particularly in regulated exocytosis. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
YM-254890 is a Gq/11 inhibitor that indirectly influences Rab3A. By targeting Gq/11 signaling, YM-254890 modulates vesicle trafficking indirectly. The disruption of Gq/11 activity impacts cellular events involving Rab3A, providing an indirect means to inhibit Rab3A-mediated functions, particularly in regulated exocytosis. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is an actin polymerization inhibitor that indirectly affects Rab3A. By disrupting actin dynamics, Latrunculin A modulates vesicle trafficking indirectly. The impact on actin-dependent processes results in altered cellular events involving Rab3A, providing an indirect means to inhibit Rab3A-dependent functions, particularly in regulated exocytosis. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT1864 is a selective inhibitor of Rac family small GTPases, indirectly influencing Rab3A. By targeting Rac GTPases, EHT1864 modulates vesicle trafficking indirectly. The disruption of Rac GTPase activity impacts cellular events involving Rab3A, providing an indirect means to inhibit Rab3A-mediated functions, particularly in regulated exocytosis. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex, indirectly affecting Rab3A. By inhibiting Arp2/3-mediated actin polymerization, CK666 modulates vesicle trafficking indirectly. The disruption of Arp2/3 activity impacts cellular events involving Rab3A, providing an indirect means to inhibit Rab3A-dependent functions, particularly in regulated exocytosis. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK869 is a selective inhibitor of the actin-related protein 2/3 (Arp2/3) complex, indirectly influencing Rab3A. By inhibiting Arp2/3-mediated actin polymerization, CK869 modulates vesicle trafficking indirectly. The disruption of Arp2/3 activity impacts cellular events involving Rab3A, providing an indirect means to inhibit Rab3A-mediated functions, particularly in regulated exocytosis. | ||||||