Rab 28 Activators
Rab28 Activators are a diverse set of chemical compounds that indirectly or directly enhance the functional activity of Rab28, each interacting with the protein through distinct mechanisms within cellular signaling pathways. Compounds such as Forskolin and 8-Bromo-cAMP work by raising intracellular levels of cAMP, which in turn activates PKA. PKA can phosphorylate Rab28 or associated regulatory proteins, which may lead to an increase in Rab28's GTPase activity, crucial for its role in vesicular trafficking and fusion. Similarly, GTPγS and GTP, by acting as a GTP analog and a natural ligand, respectively, bind to and stabilize the GTP-bound state of Rab28, thereby promoting its active role in membrane transport. In addition, PMA acts as a PKC activator and could potentially enhance Rab28's function through PKC-mediated phosphorylation pathways. Brefeldin A, by disrupting Golgi structure, may invoke a cellular response that enhances Rab28 activity to compensate for altered vesicular transport.
Rab28's activity are inhibitors of protein prenylation, such as Farnesyltransferase and Geranylgeranyltransferase inhibitors. By blocking Rab28's lipid modifications, these inhibitors might increase the pool ofRab28 Activators are a diverse set of chemical compounds that indirectly or directly enhance the functional activity of Rab28, each interacting with the protein through distinct mechanisms within cellular signaling pathways. Compounds such as Forskolin and 8-Bromo-cAMP work by raising intracellular levels of cAMP, which in turn activates PKA. PKA can phosphorylate Rab28 or associated regulatory proteins, which may lead to an increase in Rab28's GTPase activity, crucial for its role in vesicular trafficking and fusion. Similarly, GTPγS and GTP, by acting as a GTP analog and a natural ligand, respectively, bind to and stabilize the GTP-bound state of Rab28, thereby promoting its active role in membrane transport. In addition, PMA acts as a PKC activator and could potentially enhance Rab28's function through PKC-mediated phosphorylation pathways. Brefeldin A, by disrupting Golgi structure, may invoke a cellular response that enhances Rab28 activity to compensate for altered vesicular transport.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates Rab 28 by stimulating adenylate cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates protein kinase A, which in turn activates Rab 28 through phosphorylation, promoting its functional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Rab 28 via the SIRT1/AMPK pathway. It activates SIRT1, which deacetylates and activates AMPK. Active AMPK then phosphorylates and activates Rab 28, enhancing its functional activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates Rab 28 by inhibiting PDE4, leading to increased cAMP levels. Elevated cAMP activates PKA, which subsequently phosphorylates and activates Rab 28, facilitating its functional activation. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $80.00 $200.00 | 5 | |
Hesperidin activates Rab 28 through the PI3K/Akt pathway. It activates PI3K, leading to Akt phosphorylation. Active Akt then phosphorylates and activates Rab 28, promoting its functional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates Rab 28 by inhibiting tyrosine kinases, leading to reduced phosphorylation and inactivation of GTPase-activating proteins (GAPs). This inhibition results in sustained activation of Rab 28, enhancing its functional activity. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin activates Rab 28 through inhibition of NF-κB signaling. By suppressing NF-κB activation, luteolin prevents the degradation of Rab 28, leading to its accumulation and functional activation within cells. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates Rab 28 via the AMPK pathway. It activates AMPK, which phosphorylates and activates Rab 28, enhancing its functional activity in cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates Rab 28 by inhibiting mTOR signaling. Inhibition of mTOR by EGCG results in increased Rab 28 activity, facilitating its functional activation and subsequent cellular processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates Rab 28 through the Nrf2 pathway. It activates Nrf2, which translocates to the nucleus and upregulates Rab 28 expression, leading to enhanced functional activation of the protein in cells. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin activates Rab 28 by inhibiting the MAPK pathway. By suppressing MAPK signaling, naringenin prevents Rab 28 degradation, thereby promoting its accumulation and functional activation within cells. | ||||||