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Rab 28 Antibody (2C6): sc-517146

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  • Rab 28 Antibody (2C6) is a mouse monoclonal IgG2a κ Rab 28 antibody provided at 100 µg/ml
  • raised against amino acids 1-95 representing full length Rab 28 of human origin
  • recommended for detection of Rab 28 of human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 28 Antibody (2C6). This work is in progress.

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    Rab 28 Antibody (2C6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Rab 28 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Rab 28 (2C6) antibody is available as a non-conjugated format. Rab 28 protein, also known as MGC41862, is a member of the small GTPase superfamily and plays a crucial role in intracellular transport and signaling pathways, particularly in the regulation of organelle trafficking and cellular metabolism. This 221 amino acid protein is unique within the Rab family, exhibiting only 31 to 33% amino acid identity with other Rab proteins such as Rab 1A, Rab 6, Rab 11, and Rab 13, highlighting its distinct functional role. Rab 28 is expressed in two isoforms, S and L, which arise from alternative splicing; isoform S is widely distributed across various tissues including the cortex, liver, kidney, skeletal muscle, adipose tissue, and urothelium, while isoform L is predominantly found in the testis. The conservation of the Rab 28 gene across species such as chimpanzee, dog, cow, mouse, rat, chicken, and C. elegans, along with its mapping to human chromosome 4p15.33, underscores its evolutionary significance. Additionally, pseudogenes of the Rab 28 gene are located on chromosomes 9 and X, indicating a complex genetic landscape surrounding this important protein.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Rab 28 Antibody (2C6) References:

    1. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.  |  Pereira-Leal, JB. and Seabra, MC. 2000. J Mol Biol. 301: 1077-87. PMID: 10966806
    2. The Rab GTPase family.  |  Stenmark, H. and Olkkonen, VM. 2001. Genome Biol. 2: REVIEWS3007. PMID: 11387043
    3. Towards complete sets of farnesylated and geranylgeranylated proteins.  |  Maurer-Stroh, S., et al. 2007. PLoS Comput Biol. 3: e66. PMID: 17411337
    4. Large nucleotide-dependent conformational change in Rab28.  |  Lee, SH., et al. 2008. FEBS Lett. 582: 4107-11. PMID: 19026641
    5. Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini.  |  Brauers, A., et al. 1996. Eur J Biochem. 237: 833-40. PMID: 8647132

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Rab 28 Antibody (2C6)

    sc-517146
    100 µg/ml
    $316.00

    Have you tested the anti-Rab 28 Antibody (2C6): sc-517146 for endogenous protein expression?

    Asked by: Guoxin
    Thank you for your question. Please contact your local distributor or technical service for further assistance.
    Answered by: Dallas Tech Service
    Date published: 2021-04-20

    I am using Rab 28 (2C6): sc-517146 monoclonal antibody for immunoprecipitation, how much antibody should I use?

    Asked by: Randy McDonald
    Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
    Answered by: Technical Support
    Date published: 2017-04-05
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant Rab 28 by Western blot. -SCBT QC
    Date published: 2023-09-14
    Rated 5 out of 5 by from Very nic resultI used the product and diluted in TBST(1:200),4℃ overnight, the band looks very nice.
    Date published: 2017-05-28
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    Rab 28 Antibody (2C6) is rated 5.0 out of 5 by 2.
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