Rab 1A Activators
The Rab 1A activators represent a specialized group of chemicals designed to modulate the activity of Rab 1A, a key member of the Rab GTPase family involved in regulating intracellular vesicle trafficking and membrane dynamics. These compounds exert their effects through precise interactions with specific cellular pathways, influencing the activation of Rab 1A and its subsequent roles in cellular processes. Brefeldin A is a prominent member of this chemical class that activates Rab 1A by inhibiting the function of guanine nucleotide exchange factors (GEFs) involved in Rab protein activation. Specifically, Brefeldin A disrupts vesicular trafficking pathways by interfering with GEFs, leading to the activation of Rab 1A. This activation is crucial for the regulation of membrane transport processes within the cell.
Another notable activator is Golgicide A, which activates Rab 1A by specifically inhibiting the activity of the GEF GBF1. By disrupting GBF1, Golgicide A enhances the activation of Rab 1A at the Golgi apparatus, influencing vesicular trafficking. This highlights the intricate regulation of Rab 1A activation within specific cellular compartments. SecinH3 is a chemical activator that modulates Rab 1A by inhibiting the GEF Sec2. The inhibition of Sec2 by SecinH3 results in increased activation of Rab 1A, contributing to the regulation of endocytic processes and vesicle trafficking. These Rab 1A activators collectively illustrate the targeted manipulation of cellular pathways to influence the activity of Rab 1A. Understanding the specific biochemical and cellular mechanisms impacted by each compound provides valuable insights into the molecular intricacies governing Rab 1A activation. This detailed knowledge opens avenues for targeted interventions in cellular processes and applications in research and biotechnology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a non-selective inhibitor of Cdc42, another small GTPase. By inhibiting Cdc42, ML141 indirectly activates Rab 1A. The inhibition of Cdc42 can lead to the compensatory activation of other GTPases, including Rab 1A, to maintain cellular homeostasis in vesicle trafficking processes. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A activates Rab 1A by specifically inhibiting the activity of the guanine nucleotide exchange factor (GEF) GBF1 (Golgi-specific Brefeldin A resistance factor 1). This inhibition disrupts the regulation of Rab 1A activation at the Golgi apparatus, resulting in enhanced Rab 1A activity and modulation of vesicular trafficking. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC23766 is primarily an inhibitor of Rac1, another member of the Rho family of GTPases. Similar to ML141, its role in activating Rab 1A is through indirect mechanisms. By inhibiting Rac1, NSC23766 can cause a compensatory upregulation or activation of other GTPases, including Rab 1A, balancing the intracellular vesicle trafficking pathways. | ||||||
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid | 314042-01-8 | sc-503400 | 10 mg | $300.00 | ||
This compound activates Rab 1A through the inhibition of the guanine nucleotide exchange factor (GEF) Rabex-5. By disrupting Rabex-5 activity, CID 1067700 enhances the activation of Rab 1A, leading to its involvement in the regulation of endocytic processes and vesicle trafficking. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 activates Rab 1A by inhibiting the guanine nucleotide exchange factor (GEF) Sec2. The inhibition of Sec2 activity results in increased activation of Rab 1A and its participation in the regulation of vesicle trafficking, particularly in the context of secretory pathways. | ||||||
CGS 15943 | 104615-18-1 | sc-203544 sc-203544A | 10 mg 50 mg | $87.00 $398.00 | 4 | |
CGS 15943 activates Rab 1A by influencing adenosine receptors. Its action on adenosine receptors modulates cellular signaling pathways that indirectly lead to the activation of Rab 1A, contributing to its involvement in the regulation of vesicular trafficking and membrane dynamics. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL 278 activates Rab 1A by inhibiting the guanine nucleotide exchange factor (GEF) Rabex-5. Through the inhibition of Rabex-5, ZCL 278 enhances the activation of Rab 1A, contributing to its participation in the regulation of vesicular trafficking and intracellular membrane dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 activates Rab 1A by modulating Rho-associated protein kinase (ROCK) signaling. Its action on ROCK influences cellular pathways that indirectly lead to the activation of Rab 1A, contributing to its involvement in the regulation of vesicle trafficking and membrane dynamics. | ||||||
DBeQ | 177355-84-9 | sc-499943 | 10 mg | $330.00 | 1 | |
DBeQ activates Rab 1A by inhibiting the activity of the guanine nucleotide exchange factor (GEF) DENND4C. Through the inhibition of DENND4C, DBeQ enhances the activation of Rab 1A, contributing to its participation in the regulation of vesicular trafficking and intracellular membrane dynamics. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
EHT 1864 activates Rab 1A by inhibiting the activity of the guanine nucleotide exchange factor (GEF) DOCK7. Through the inhibition of DOCK7, EHT 1864 enhances the activation of Rab 1A, contributing to its involvement in the regulation of vesicular trafficking and intracellular membrane dynamics. | ||||||