Rab 1A Antibody (G-10): sc-377201

Rab 1A Antibody (G-10) is a mouse monoclonal IgM kappa antibody that detects Rab 1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 1A antibody (G-10) is available as a non-conjugated format. Rab 1A protein plays a crucial role in intracellular transport, particularly in vesicle movement between the endoplasmic reticulum and Golgi apparatus, which is essential for proper protein secretion. Rab 1A protein localizes primarily in the cytoplasm and regulates vesicle trafficking, ensuring proteins reach correct destinations within cells. Precise Rab 1A localization remains vital since disruption can lead to cellular dysfunction and has been linked to various diseases, including neurodegenerative disorders. Rab 1A protein interacts with several effector proteins that facilitate docking and fusion of transport vesicles with target membranes, highlighting its importance in maintaining cellular homeostasis.

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Rab 1A Antibody (G-10) References:

1. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
2. Cloning of a Rab3 isotype predominantly expressed in adipocytes.  |  Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
3. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
4. The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.  |  Zhang, Y., et al. 2019. J Immunol. 202: 194-206. PMID: 30455398
5. A familial 2p14 microdeletion disrupting actin-related protein 2 and Ras-related protein Rab-1A genes with intellectual disability and language impairment.  |  Tabata, K., et al. 2022. Eur J Med Genet. 65: 104446. PMID: 35134569
6. Rab GDP dissociation inhibitor: putting rab GTPases in the right place.  |  Pfeffer, SR., et al. 1995. J Biol Chem. 270: 17057-9. PMID: 7615494
7. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.  |  Chen, YT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6508-12. PMID: 7688123
8. Coatomers and SNAREs in promoting membrane traffic.  |  Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
9. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
10. The role of GTP-binding proteins in transport along the exocytic pathway.  |  Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
11. Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.  |  Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
12. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.  |  Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 1A Antibody (G-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 1A Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 1A Antibody (G-10) Specifications

Alternate Product Name: Rab 1A

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 171-209

Epitope Target: Rab 1A

Epitope Species: human

Product Reactivity/Detection: Rab 1A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Rab 1A Antibody (G-10): P: Blocking Peptide

The preferred Rab 1 antibody is Rab 1 Antibody (E-8): sc-515308.