Rab 11A Activators
Common Rab 11A Activators include, but are not limited to SB 203580 CAS 152121-47-6, Genistein CAS 446-72-0, Resveratrol CAS 501-36-0, AICAR CAS 2627-69-2 and PGE2 CAS 363-24-6.
Rab11A activators are molecules or mechanisms that enhance the activity of Rab11A, a member of the Rab GTPase family. Rab11A is a crucial regulator of intracellular vesicular trafficking, particularly in the recycling endosomal pathway. These activators typically facilitate the exchange of GDP for GTP, which switches Rab11A into its active state. In this active form, Rab11A plays a pivotal role in coordinating the transport of vesicles loaded with cellular cargo, including proteins and lipids. It regulates the recycling endosomes, which are central hubs for sorting and delivering various components to their specific destinations within the cell.
Understanding the activation of Rab11A is fundamental to comprehending the intricacies of intracellular vesicular transport and its impact on cellular processes such as receptor recycling, cytokinesis, and cell polarity maintenance. Research into Rab11A activators provides insights into the regulation of these processes and can have implications for understanding cellular functions. In summary, Rab11A activators modulate Rab11A's activity, influencing intracellular vesicular trafficking and recycling pathways in eukaryotic cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor that prevents inhibitory phosphorylation and exclusion from the nucleus of ATF2, allowing it to dimerize and bind CRE sites regulating RAB11A. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
HDAC inhibitor that acetylates histones at the RAB11A locus, favoring an open chromatin conformation for transcription factor recruitment. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
SIRT1 activator that may positively modulate acetylation state of regulatory proteins near the RAB11A promoter. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator that stimulates CREB pathway components like CRTC2, enhancing their binding to cAMP response motifs controlling RAB11A expression. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
EP2/EP4 receptor agonist activating cAMP/PKA cascade and phosphorylation of CREB. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
ER antagonist that inhibits E2-induced repression of RAB11A activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Although primarily known as a Golgi-disrupting agent, Brefeldin A's effects on membrane trafficking could influence Rab11a activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
As an ionophore that disrupts endosomal pH, Monensin might affect endosomal recycling and Rab11a activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
This PI3K inhibitor can influence various trafficking pathways and may indirectly affect Rab11a. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, Rapamycin can influence cellular trafficking, possibly affecting Rab11a activity. | ||||||