R1 Activators
R1 activators encompass a diverse range of chemicals that indirectly influence R1 through their action on various signaling pathways and cellular processes. These activators are characterized by their ability to modulate key cellular mechanisms, leading to an environment that promotes R1 activity or expression. The majority of these compounds act as activators of specific signaling pathways. For instance, Forskolin, Dibutyryl-cAMP, PMA, and TPA modulate pathways involving cAMP and PKC, respectively. These pathways are crucial for various cellular processes, including growth, survival, and differentiation. By influencing these pathways, these chemicals create an environment that can enhance R1 activity.
Other compounds like Ionomycin, Anisomycin, Insulin, Hydrogen Peroxide, Retinoic Acid, and Zinc Sulfate act through different mechanisms, such as altering intracellular calcium levels, inducing stress responses, activating growth factor receptors, modulating oxidative stress, influencing gene expression, and altering metal ion homeostasis. Each of these actions can lead to changes in cellular signaling or state, ultimately creating conditions that favor R1 activation or increased activity. In summary, R1 activators function by modulating various signaling networks and cellular states. This modulation can indirectly activate R1, leading to its enhanced activity or expression. These activators target a wide range of cellular processes, from kinase signaling and cAMP pathways to growth factor signaling and oxidative stress responses, each contributing to the indirect activation of R1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which can then modulate various cellular processes. By increasing cAMP and subsequently activating PKA, Forskolin can indirectly stimulate pathways or cellular states that enhance R1 activity or expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, such as the calmodulin-dependent kinases or calcineurin, which can influence various cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). Activation of PKC can lead to the modulation of numerous signaling pathways and cellular processes. Through these changes, PMA can indirectly stimulate cellular conditions or pathways that enhance R1 activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases like JNK. Activation of JNK can influence various signaling pathways and cellular processes, potentially leading to conditions that favor the activation or increased expression of R1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor, triggering the PI3K/Akt and the MAPK/ERK pathways. Activation of these pathways can lead to various cellular effects, including promoting growth and survival signals. These pathways, when activated, can create a cellular environment conducive to the activation or increased activity of R1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP. By increasing intracellular cAMP levels, it activates PKA, influencing various cellular processes. This activation can indirectly create conditions that enhance R1 activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide acts as an oxidative agent and can modulate redox-sensitive signaling pathways. Through its influence on these pathways, hydrogen peroxide can indirectly create cellular conditions that enhance R1 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences gene expression by activating retinoic acid receptors. This activation can lead to changes in cellular differentiation and growth. Through these changes, retinoic acid can indirectly create conditions favorable for the activation or increased activity of R1. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate can increase intracellular zinc levels, influencing various zinc-dependent enzymes and transcription factors. This alteration in zinc homeostasis can indirectly lead to the activation of pathways or modulation of cellular states that enhance R1 activity. | ||||||