R-Spondin4 Activators
R-Spondin4 Activators are a diverse set of chemical compounds that enhance the functional activity of R-Spondin4 by targeting specific signaling pathways integral to its mechanism of action. Lithium Chloride, for example, by inhibiting GSK-3β, indirectly leads to the accumulation of β-catenin, a core component of the Wnt/β-catenin signaling pathway with which R-Spondin4 interacts. This stabilization of β-catenin facilitates the formation of a receptor-ligand complex with LGR4/5/6, thereby amplifying the Wnt signaling. Forskolin works by a different mechanism, raising intracellular cAMP, which subsequently activates PKA. This activation can result in phosphorylation events that enhance cellular responses to Wnt ligands, thereby supporting the activity of R-Spondin4. Biochanin A, acting through estrogen receptor modulation, and Ionomycin, by increasing intracellular calcium, can both indirectly contribute to the enhancement of R-Spondin4 activity by modulating hormonal and calcium-dependent signaling pathways that intersect with Wnt signaling.
The second group of activators includes PMA, which activates PKC and has implications for Wnt/β-catenin pathway regulation, again complementing the role of R-Spondin4 in this signaling cascade. Several specific GSK-3β inhibitors such as SB-216763, WAY-316606, Chir 99021, and QS 11 uniformly contribute to the enhancement of R-Spondin4's function by promoting β-catenin stabilization, thus indirectly potentiating Wnt signaling. SKL2001 uniquely disrupts the Axin/β-catenin interaction, which can result in an increased activity of R-Spondin4. Nicotinamide, through sirtuin inhibition, may lead to enhanced acetylation of β-catenin, providing another avenue for R-Spondin4 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride directly influences the Wnt/β-catenin signaling pathway by inhibiting GSK-3β, resulting in the stabilization and accumulation of β-catenin. Elevated β-catenin levels can enhance R-Spondin4 activity by forming complexes with LGR4/5/6, which are receptors for R-Spondin4, thereby potentiating the Wnt signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cyclic AMP (cAMP) levels, activating protein kinase A (PKA). PKA phosphorylation can lead to changes in the cellular environment that support R-Spondin4's role in Wnt signal potentiation by increasing the cellular response to Wnt ligands. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
Biochanin A, an isoflavone, acts as a modulator of estrogen receptors. By activating estrogen receptors, it can indirectly enhance Wnt signaling which is synergistic with R-Spondin4's role in potentiating this pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can modulate various calcium-dependent signaling pathways. Elevated calcium levels can indirectly enhance R-Spondin4 activity by influencing Wnt signaling components that are calcium-sensitive. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can modulate the Wnt/β-catenin pathway. PKC activation can lead to an enhanced response to R-Spondin4's signaling effects by increasing Wnt-responsive gene expression. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a GSK-3β inhibitor, which leads to the stabilization of β-catenin, enhancing Wnt/β-catenin signaling, a pathway that R-Spondin4 potentiates. | ||||||
SKL2001 | 909089-13-0 | sc-507410 | 10 mg | $123.00 | ||
SKL2001 activates the Wnt/β-catenin signaling pathway by disrupting the Axin/β-catenin interaction, which could enhance the activity of R-Spondin4 in potentiating Wnt signaling. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, can act as an inhibitor of sirtuins, which are NAD+-dependent deacetylases. Sirtuin inhibition may enhance Wnt signaling by increasing acetylation of β-catenin, thus potentially enhancing R-Spondin4 activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
Chir 99021 is a selective GSK-3β inhibitor that stabilizes β-catenin, thereby enhancing Wnt/β-catenin signaling, which can indirectly increase the activity of R-Spondin4. | ||||||
Wnt Synergist, QS11 | 944328-88-5 | sc-222417 sc-222417A | 5 mg 25 mg | $141.00 $607.00 | ||
QS 11 is an inhibitor of GSK-3β, leading to the stabilization and accumulation of β-catenin in the nucleus, which can enhance the signaling pathways that R-Spondin4 potentiates. | ||||||