Biochanin A (CAS 491-80-5)

Biochanin A, an isoflavone, is a natural plant phytoestrogen which has been reported to be an antiproliferative and anti-inflammatory agent. Studies show that this compound inhibits iNOS expression and lipopolysacharide (LPS)-induced nitric oxide production in macrophages. Additionally, Biochanin A displays the ability to block phosphorylation of IκBα and p38 MAPK, which prevents NF-κB activation. Furthermore, Biochanin A has been observed to suppress IL-6, IL-1β, and TNF-α production.

Literaturhinweise

1. Chae, Y.H. et al. 1992. Chem. Biol. Interact. 82(2): 181-193. PMID: 1568269

2. Jing, Y. and Waxman, S. 1995. Anticancer Res. 15(4): 1147-1152. PMID: 7653993

3. Rooke, N. et al. 2000. J. Med. Chem. 43(22): 4169-4179. PMID: 11063613

4. Khan, I.A. et al. 2000. J. Nat. Prod. 63(10): 1414-1416. PMID: 11076565

5. Tasdemir, D. et al. 2006. J. Med. Chem. 49(11): 3345-3353. PMID: 16722653

6. Salem, M.M. and Werbovetz, K.A. 2006. J. Nat. Prod. 69(1): 43-49. PMID: 16441066

7. Schuster, D. et al. 2008. J. Med. Chem. 51(14): 4188-4199. PMID: 18533708

8. Thors, L. et al. 2010. Br. J. Pharmacol. 160(3): 549-560. PMID: 20590565

9. Kole, L. et al. 2011. Eur. J. Pharmacol. 653(1-3): 8-15. PMID: 21147093