QSK Activators
QSK (SIK family kinase 3) activators are a class of chemical compounds known for their unique ability to modulate the activity of the protein kinase family member, QSK (SIK3). These activators are characterized by their capacity to enhance the enzymatic function of QSK, a serine/threonine protein kinase that plays a crucial role in various cellular processes. The term QSK activators specifically refers to small molecules or chemical entities that, upon interaction with QSK, induce a conformational change or allosteric modification, leading to an increase in the kinase's activity. This class of compounds can serve as valuable tools in elucidating the physiological and pathological functions of QSK in various biological contexts.
The activation of QSK is significant due to its involvement in intracellular signaling pathways. QSK, a member of the Salt-Inducible Kinase (SIK) family, regulates processes like gene expression, cellular metabolism, and ion transport. By modulating QSK activity, these activators can impact downstream signaling cascades and cellular responses. Researchers have been investigating QSK activators for their potential to influence cell differentiation, gene transcription, and metabolic regulation, shedding light on the complex regulatory networks within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels and indirectly increasing QSK activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMP-activated protein kinase (AMPK), indirectly increasing QSK. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Elevates intracellular calcium levels, indirectly increasing QSK through calcium signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Inhibits phosphodiesterase (PDE), increasing cAMP levels and potentially increasing QSK activity indirectly. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $324.00 | 1 | |
Activates protein kinase A (PKA), indirectly increasing QSK through PKA-mediated phosphorylation. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Inhibits calmodulin, potentially increasing QSK indirectly by modulating calcium-dependent signaling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylases (HDACs), indirectly increasing QSK-regulated gene expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Acts as an agonist of peroxisome proliferator-activated receptor (PPAR), indirectly increasing QSK activity through related metabolic pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates sirtuins and increases NAD+ metabolism, indirectly increasing QSK activity due to its role in cellular processes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid with anti-inflammatory effects, indirectly increasing QSK by regulating gene expression. | ||||||