PTH2 Receptor Activators
The PTH2 receptor is a G protein-coupled receptor (GPCR) that belongs to a family of receptors responsive to the parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). While the PTH1 receptor is primarily involved in regulating calcium metabolism and bone remodeling, the PTH2 receptor's physiological role is less clearly defined. It is known to have a high affinity for PTHrP and is expressed in various tissues, including the brain and pancreas, suggesting a potential role in neuroendocrine and metabolic pathways.
The PTH2 receptor is encoded by the PTH2R gene and is structurally characterized by the typical seven-transmembrane domain architecture of GPCRs. Upon binding its ligand, the PTH2 receptor activates intracellular signaling cascades involving the second messenger cAMP. This activation can lead to a variety of cellular responses, including changes in enzyme activity, gene expression, and cellular secretion processes.Research into the PTH2 receptor has been less extensive than for the PTH1 receptor, but it is thought to be involved in central nervous system functions and has been implicated in pain modulation and thermoregulation. Its expression in pancreatic tissue also suggests it may play a role in the regulation of pancreatic functions, although these effects are not fully understood.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
It activates adenylyl cyclase, increasing cAMP, which may enhance PTH2 receptor expression through cAMP response elements. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This green tea polyphenol may modulate signaling pathways that control GPCR gene expression, including PTH2 receptor. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, lithium chloride may affect Wnt signaling, potentially influencing PTH2 receptor expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As a retinoid, tretinoin can regulate gene expression and might influence PTH2 receptor expression during differentiation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This HDAC inhibitor can alter chromatin structure and increase gene expression, potentially including PTH2 receptor. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Another HDAC inhibitor that can change gene expression profiles, possibly affecting PTH2 receptor expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that may upregulate genes with cAMP-responsive elements, potentially including PTH2 receptor. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
By affecting DNA synthesis and repair, methotrexate could influence the expression of various genes, including PTH2 receptor. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
This chemotherapy agent can cause DNA damage, potentially altering the expression of genes involved in stress response, including PTH2 receptor. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
As a SERM, tamoxifen can alter the transcription of estrogen-responsive genes, which may include PTH2 receptor. | ||||||