PTEN Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VO-OHpic (Vanadium Oxide Hydroxypicolinate) | 675848-25-6 | sc-507478 | 10 mg | $276.00 | ||
VO-OHpic is a vanadium-based PTEN inhibitor. It has been reported to inhibit PTEN activity and promote cell proliferation and survival in certain cancer cell lines. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound found in turmeric, has been reported to inhibit PTEN in certain cancer cell lines. It exhibits anticancer properties and is being investigated for its potential in cancer research. | ||||||
SF1126 | 936487-67-1 | sc-391584 sc-391584A | 5 mg 10 mg | $1050.00 $2240.00 | 7 | |
SF1126 is a dual inhibitor of PTEN and PI3K (Phosphoinositide 3-kinase). It has been developed as a targeted therapy for various cancers, aiming to simultaneously inhibit the PI3K/Akt pathway and restore PTEN function. | ||||||
bpV(HOpic) | 722494-26-0 | sc-221377 sc-221377A | 5 mg 25 mg | $97.00 $338.00 | 19 | |
bpV(HOpic) acts as a potent inhibitor of PTEN, showcasing remarkable specificity through its unique binding interactions. The compound's phosphonate moiety engages in strong hydrogen bonding with the active site of PTEN, effectively disrupting its phosphatase activity. This selective inhibition alters downstream signaling pathways, influencing cellular processes. Additionally, bpV(HOpic) exhibits favorable kinetics, allowing for rapid modulation of PTEN activity in various biological contexts. | ||||||
bpV(pic) | 148556-27-8 | sc-221379 sc-221379A | 5 mg 25 mg | $88.00 $334.00 | 11 | |
bpV(pic) serves as a selective inhibitor of PTEN, characterized by its unique ability to form stable complexes with the enzyme's active site. The compound's distinct structural features facilitate specific interactions that hinder PTEN's phosphatase function, leading to altered cellular signaling dynamics. Its kinetic profile allows for swift engagement and disengagement with PTEN, enabling precise control over phosphatidylinositol signaling pathways and influencing cellular responses effectively. | ||||||
bpV(bipy) trihydrate | sc-311300 | 5 mg | $175.00 | 1 | ||
bpV(bipy) trihydrate acts as a potent modulator of PTEN activity, distinguished by its capacity to engage in specific hydrogen bonding and π-π stacking interactions with the enzyme. This compound exhibits a unique binding affinity that stabilizes the enzyme's conformation, thereby impacting its phosphatase activity. The intricate molecular dynamics of bpV(bipy) trihydrate facilitate nuanced alterations in signaling cascades, contributing to the regulation of cellular processes through its selective inhibition. | ||||||
PTP CD45 Inhibitor | 345630-40-2 | sc-222223A sc-222223 | 1 mg 5 mg | $104.00 $306.00 | 1 | |
PTP CD45 Inhibitor functions as a selective modulator of phosphatase activity, characterized by its ability to disrupt key protein-protein interactions within signaling pathways. This compound exhibits a unique mechanism of action by altering the conformational dynamics of CD45, leading to a decrease in its phosphatase function. The inhibitor's specific binding interactions can influence downstream signaling events, thereby modulating cellular responses with precision. | ||||||
VO-OHpic trihydrate | 476310-60-8 | sc-216061 sc-216061A | 10 mg 25 mg | $179.00 $398.00 | 9 | |
VO-OHpic trihydrate acts as a potent inhibitor of PTEN, showcasing a distinctive ability to stabilize the enzyme's inactive conformation. This compound engages in specific hydrogen bonding and hydrophobic interactions, effectively disrupting the enzyme's catalytic site. Its unique structural features facilitate selective binding, influencing the kinetics of phosphatase activity and altering lipid signaling pathways, thereby impacting cellular homeostasis and metabolic processes. | ||||||