Molecular structure of bpV(bipy) trihydrate
bpV(bipy) trihydrate
See product citations (1)
Alternate Names:
Potassium bisperoxo (bipyridine) oxovanadate (V) trihydrate; PTEN Inhibitor II; PTP Inhibitors XIV
Application:
bpV(bipy) trihydrate is a phosphotyrosine phosphatase and PTEN inhibitor and IRK activator
Molecular Weight:
380.27
Molecular Formula:
K[VO(O2)2C10H8N2]·3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation). Also an activator of insulin receptor kinase (IRK). Also shown to be a potent inhibitor of PTEN (IC50 = 18 nM).
bpV(bipy) trihydrate References
- Bisperoxovanadium compounds are potent PTEN inhibitors. | Schmid, AC., et al. 2004. FEBS Lett. 566: 35-8. PMID: 15147864
- Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer. | Dirican, E. and Akkiprik, M. 2017. Tumour Biol. 39: 1010428317695529. PMID: 28351303
- Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. | Posner, BI., et al. 1994. J Biol Chem. 269: 4596-604. PMID: 8308031
Inhibitor of:
PTEN, and PTP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
bpV(bipy) trihydrate, 5 mg | sc-311300 | 5 mg | $175.00 |