PSTPIP1 Inhibitors
PSTPIP1 inhibitors target the PSTPIP1 (Proline-Serine-Threonine Phosphatase-Interacting Protein 1) protein, also known as CD2-binding protein 1 (CD2BP1). PSTPIP1 is a cytoskeletal adaptor protein that plays a crucial role in regulating the dynamics of the actin cytoskeleton and modulating immune cell functions. This protein interacts with a variety of cellular partners, including the actin-binding protein WASP (Wiskott-Aldrich Syndrome Protein) and the tyrosine kinase Pyk2, which are involved in actin cytoskeleton rearrangement and signaling pathways in immune cells.
Inhibitors of PSTPIP1 interact with this protein and potentially disrupt its interactions with other cellular components or affect its functions related to actin cytoskeleton regulation and immune cell signaling. These inhibitors may operate through various mechanisms, such as binding to specific domains of PSTPIP1 or altering its conformation. By inhibiting PSTPIP1, these compounds can potentially interfere with the intricate processes governing immune cell activation, actin cytoskeleton dynamics, and cellular responses to external stimuli. Research on PSTPIP1 inhibitors is primarily focused on understanding the molecular mechanisms by which PSTPIP1 modulates immune cell functions and cytoskeletal rearrangements, providing insights into the complex regulatory networks that govern immune responses and cellular motility.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis which may lead to a reduction in PSTPIP1 protein levels as part of the global protein inhibition. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, possibly reducing PSTPIP1 mRNA synthesis as part of global transcription inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that may alter protein synthesis, potentially reducing the expression of PSTPIP1. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
A compound that binds to DNA, potentially changing the transcription of specific genes, including PSTPIP1. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that has been shown to inhibit the transcription of a wide range of genes, possibly affecting PSTPIP1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
A compound known to alter endosomal pH and could affect signaling pathways, potentially impacting PSTPIP1 gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor which may affect inflammatory response pathways and subsequently alter gene expression, including PSTPIP1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of the JNK signaling which might influence the activity of transcription factors that regulate PSTPIP1 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that might alter the AKT signaling pathway and affect transcriptional regulation of genes like PSTPIP1. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor that might induce stress responses, potentially influencing the expression of various genes. | ||||||