PSG7 Activators
PSG7 can engage various signaling pathways to induce the functional activation of this protein. Epinephrine, Isoproterenol, Terbutaline, and Dopamine are all agonists that interact with G protein-coupled receptors (GPCRs), which can lead to an increase in intracellular cyclic AMP (cAMP) levels. This elevation in cAMP results in the activation of protein kinase A (PKA), an enzyme that can phosphorylate a multitude of proteins. The phosphorylation by PKA is a common post-translational modification that can regulate protein function, and in the context of PSG7, this modification can enhance its functional activity. Similarly, Forskolin directly stimulates adenylyl cyclase, the enzyme responsible for the conversion of ATP to cAMP, leading to the same downstream activation of PKA. The increased activity of PKA facilitates the phosphorylation and subsequent activation of PSG7.
IBMX and Rolipram function as inhibitors of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, these inhibitors indirectly contribute to the accumulation of cAMP in the cell, fostering an environment for PKA activation. Prostaglandin E2 (PGE2) and Histamine operate through their respective GPCRs to also raise cAMP levels, further potentiating PKA activation. Glucagon and Adenosine, through their specific receptors, similarly induce the production of cAMP, reinforcing the activation pathway leading to PKA-mediated phosphorylation. Finally, Anagrelide inhibits phosphodiesterase III, contributing to the rise in cAMP levels and energizing the PKA activation pathway. Each of these chemicals, by increasing cAMP levels or directly stimulating PKA, presents a pathway for the phosphorylation and activation of PSG7, delineating a clear biochemical route for its functional activation within the cellular context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with adrenergic receptors, which can lead to a cascade of intracellular events resulting in the activation of protein kinase A (PKA). PKA can then phosphorylate proteins, including PSG7, which may enhance its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels, which activates PKA. Activated PKA can phosphorylate target proteins such as PSG7, potentially increasing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, can increase cAMP levels via stimulation of Gs protein-coupled receptors, leading to PKA activation. PKA activation can subsequently phosphorylate and activate PSG7. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP, leading to its accumulation. Elevated cAMP activates PKA, which may then phosphorylate and activate PSG7. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G protein-coupled receptors, which can lead to increased intracellular cAMP levels and activation of PKA. PKA can phosphorylate various proteins, potentially including PSG7, leading to activation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to H2 receptors, leading to an increase in intracellular cAMP and activation of PKA. PKA may phosphorylate PSG7, leading to its activation. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with A2 receptors that increase cAMP levels, leading to PKA activation. PKA might phosphorylate and activate PSG7 as part of its downstream effects. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like receptors, which increases cAMP levels and activates PKA. PKA can then phosphorylate various proteins, potentially including PSG7, resulting in activation. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline, a beta2-adrenergic agonist, increases intracellular cAMP levels, leading to PKA activation. PKA then might phosphorylate PSG7, leading to its activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which prevents cAMP degradation, leading to PKA activation. PKA could phosphorylate PSG7, thereby activating it. | ||||||