Chemical activators of Psg22 engage distinct cellular pathways to enhance its activity. Phorbol 12-myristate 13-acetate, a potent activator of Protein Kinase C (PKC), initiates a cascade of phosphorylation events that culminates in the activation of Psg22. Similarly, Bryostatin 1 and 1,2-Dioleoyl-sn-glycerol function as PKC agonists, leading to the phosphorylation and subsequent activation of Psg22. This phosphorylation is a critical modification that regulates Psg22, allowing it to perform its cellular functions effectively. Forskolin and 8-Bromo-cAMP, on the other hand, raise intracellular cAMP levels, which activate Protein Kinase A (PKA). PKA then phosphorylates target proteins, thereby activating Psg22. These mechanisms show that the modulation of kinase activity is a primary method for the regulation of Psg22 activity within the cell.
Further, the activation of Psg22 can be influenced by changes in intracellular calcium levels. Ionomycin and A23187 (Calcimycin), both calcium ionophores, increase the intracellular concentration of calcium, which can activate the calcium-sensitive phosphatase calcineurin or PKC, both of which can lead to the activation of Psg22. Oleic Acid and Arachidonic Acid are fatty acids that enhance PKC, which is then able to phosphorylate and activate Psg22. Anandamide activates cannabinoid receptors that are known to engage with PKC, contributing to the activation of Psg22. Ceramide activates protein phosphatases which, in turn, can dephosphorylate specific proteins resulting in the activation of Psg22. Lastly, Phosphatidylserine serves to enhance the activity of PKC, further contributing to the phosphorylation and activation of Psg22. All these chemicals interact with and modulate specific cellular pathways that converge on the activation of Psg22, ensuring its participation in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Directly activates Protein Kinase C (PKC) which then phosphorylates and activates Psg22. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium concentration, leading to the activation of calcineurin which dephosphorylates proteins that activate Psg22. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Binds to and activates PKC, which phosphorylates and activates Psg22. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
Serves as a cAMP analog to activate PKA, which then phosphorylates and activates Psg22. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Acts as a calcium ionophore to increase intracellular calcium and activate PKC, which then activates Psg22. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Enhances PKC which is involved in the phosphorylation and activation of Psg22. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Activates PKC which in turn phosphorylates and activates Psg22. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Can activate protein phosphatases that dephosphorylate proteins resulting in the activation of Psg22. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Enhances PKC activity which phosphorylates and leads to the activation of Psg22. | ||||||