PRRG2 Inhibitors
PRRG2 inhibitors represent a diverse group of compounds that can modulate the function of the PRRG2 protein, either directly or indirectly. Among the key classes of compounds that can influence PRRG2's function are calcium chelators such as EDTA and EGTA. These agents can impact the structural integrity or calcium-dependent interactions of PRRG2, given the role of calcium in various cellular processes. Actin dynamics, which play a crucial role in cellular movement and morphology, can also potentially be a target, with compounds like Latrunculin A and Cytochalasin D disrupting actin polymerization and filaments respectively.
Other compounds like Y-27632, PD98059, and PP2 delve into the realm of cellular signaling. For instance, Y-27632 inhibits Rho kinase and can influence proteins that are linked to cytoskeletal dynamics, while PD98059 targets the MEK pathway, a central signaling pathway in cells. Another notable category includes kinase inhibitors like H-89 and ML-7. Protein phosphorylation is a pivotal post-translational modification, these inhibitors can modulate PRRG2 activity through these means.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Specifically chelates calcium; if PRRG2 has calcium-binding sites, this can disrupt those interactions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Rho kinase inhibitor; for proteins like PRRG2 possibly linked to cytoskeletal dynamics. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK; if PRRG2 is affected by the MAPK pathway, this can disrupt associated signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Targets Src family kinases; relevant if PRRG2 associates or is phosphorylated by these kinases. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Influences calcium-calmodulin signaling; if PRRG2 interacts with calmodulin, this interaction can be disrupted. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Prevents actin polymerization; relevant if PRRG2's function ties to actin structures. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin filaments; for proteins like PRRG2 linked to actin dynamics, this can disrupt their role. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
PKA inhibitor; for proteins possibly influenced by PKA signaling or phosphorylation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase; relevant if PRRG2 is involved in cellular movement or adhesion. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Myosin II inhibitor; can be relevant if PRRG2 influences cellular adhesion or cytoskeletal dynamics. | ||||||