PRR20B Inhibitors
Chemical inhibitors of PRR20B function by disrupting various signaling pathways and molecular interactions that are essential for its activity within cells. Staurosporine acts as a broad-spectrum protein kinase inhibitor, targeting the phosphorylation process that is crucial for PRR20B and other proteins' functional modulation. Similarly, both wortmannin and LY294002 specifically inhibit phosphoinositide 3-kinases (PI3K), which are upstream regulators in cell signaling pathways that PRR20B may be part of. By halting PI3K activity, these inhibitors can prevent the activation of downstream targets and pathways that PRR20B needs for its role in cellular processes. Rapamycin, by inhibiting mTOR, affects the mTOR signaling pathway, which has a range of cellular functions including those related to protein synthesis that PRR20B may be involved in. Triciribine targets the Akt pathway, inhibiting survival and growth signals that could influence PRR20B's function.
Continuing with other inhibitors, Palbociclib disrupts the activity of cyclin-dependent kinases 4 and 6 (CDK4/6), which can have an impact on the cell cycle and transcriptional regulation that PRR20B might be involved in. PD98059 and U0126, both MEK inhibitors, block the MAPK/ERK pathway, which is known to be a key regulatory pathway for a variety of proteins, including PRR20B. Inhibitors like SP600125 and SB203580, which target JNK and p38 MAP kinase respectively, interfere with stress-activated protein kinase pathways that can regulate cellular responses possibly involving PRR20B. Lastly, broad-spectrum tyrosine kinase inhibitors like dasatinib and specific receptor tyrosine kinase inhibitors like sunitinib obstruct signal transduction mechanisms that are likely critical for the function of PRR20B, leading to an inhibitory effect on the protein's activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which are vital components in signal transduction pathways that can regulate various proteins, including PRR20B. By inhibiting these kinases, staurosporine disrupts the phosphorylation processes essential for the proper functioning of PRR20B. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K), which play an important role in many cellular processes, including those that may regulate the activity of PRR20B. Inhibition of PI3K can lead to reduced activation of downstream pathways that are necessary for PRR20B function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another specific inhibitor of PI3K, leading to blocked signal transduction that could be crucial for PRR20B's role in the cell. By inhibiting PI3K, LY294002 can prevent the functional activity of PRR20B within its signaling pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can disrupt the mTOR signaling pathway. Since mTOR pathways can regulate protein synthesis and other cellular functions that PRR20B may be involved in, rapamycin can inhibit the functional activity of PRR20B by disabling its regulatory pathways. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an inhibitor of the Akt pathway, which is downstream of PI3K. Akt is involved in cell survival and growth, and its inhibition by triciribine can hinder cellular processes that PRR20B may influence, thereby inhibiting PRR20B's function. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor. Although CDKs are primarily known for their role in cell cycle regulation, they also have roles in transcription and other cellular processes. Inhibition of CDK4/6 can disrupt functions that PRR20B may be a part of, thereby inhibiting its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which interferes with the MAPK/ERK pathway, a signaling pathway that can regulate various proteins and cellular functions. By inhibiting MEK, PD98059 can restrict ERK pathway signaling that may be necessary for PRR20B's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, which can prevent the activation of the MAPK/ERK pathway. This pathway's inhibition can consequently inhibit PRR20B's function if PRR20B relies on signals from the MAPK/ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the stress-activated protein kinase pathways. JNK pathways can regulate various cellular responses, and by inhibiting JNK, SP600125 can inhibit functions that PRR20B may be involved in. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor, which can block the p38 signaling pathway involved in inflammatory responses and stress. Inhibition of p38 MAP kinase can indirectly inhibit PRR20B's function if PRR20B is regulated by this pathway. | ||||||