PRR15 Inhibitors
PRR15 inhibitors are a class of chemical compounds that specifically target and impede the function of the protein PRR15 (Proline Rich 15). PRR15 is a relatively understudied protein that is encoded by the PRR15 gene. The exact biological function of PRR15 remains elusive; however, it is understood to have a role in cellular processes due to its expression patterns and protein interactions. The PRR15 inhibitors are designed to bind to this protein and alter its activity, thus affecting the downstream processes in which PRR15 is involved. These processes could encompass a wide range of cellular functions, which may be fundamental to the life cycle of cells, including their proliferation, differentiation, and other critical cellular mechanisms. The inhibitors could act at the molecular level, potentially affecting the conformation of the PRR15 protein, its stability, or its interaction with other cellular components.
The development of PRR15 inhibitors involves a thorough understanding of the protein's structure and the key domains that are crucial for its activity. By employing techniques like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and other high-throughput screening methods, scientists are able to identify potential inhibitor molecules that exhibit high specificity and affinity for PRR15. These inhibitors may be small molecules, peptides, or other forms of bioactive compounds that have been optimized for effective interaction with the target protein. The design process often includes the refinement of chemical structures to enhance the inhibitor's binding properties, while minimizing off-target effects. In the laboratory, PRR15 inhibitors are typically used in biochemical assays and cellular studies to understand the role of PRR15 in various biological pathways. By inhibiting PRR15, researchers can dissect the protein's contribution to the complex network of signaling events within a cell and gain insights into the fundamental aspects of cell biology.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can disrupt protein synthesis and cell cycle progression. Inhibition of mTOR can reduce the translation of specific mRNAs that are crucial for cell growth and may indirectly decrease the activity of PRR15, which has been implicated in cell proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which functions upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 can prevent the activation of ERK and thereby potentially reduce the expression of PRR15 if it is regulated by this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can prevent the PI3K/Akt signaling pathway. Since this pathway is involved in cell survival and growth, its inhibition may lead to decreased expression or activity of growth-related proteins like PRR15. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of MAPK/ERK pathway. This can lead to reduced transcriptional activity of genes involved in cell cycle progression, potentially downregulating PRR15 if it is controlled by this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. By blocking p38 MAPK, it may interfere with stress response pathways and inflammatory cytokine production, which might indirectly affect the stability or expression of PRR15 if it is involved in these cellular responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK pathway. Inhibition of JNK can alter transcription factor activity and thus potentially decrease the expression of proteins like PRR15 that may be regulated by stress or growth signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, similar to LY294002, and it works by impeding the PI3K/Akt pathway. This can lead to reduced cellular proliferation and survival, possibly affecting the expression or activity of PRR15. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an Akt inhibitor which may lead to apoptosis or cell cycle arrest. By inhibiting Akt, triciribine can decrease the survival signals that might be necessary for the expression or activity of proteins like PRR15. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a Hedgehog pathway inhibitor, which can suppress the signaling involved in cell differentiation and proliferation. If PRR15 is part of the transcriptional program induced by Hedgehog signaling, cyclopamine may decrease its activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor which can lead to the accumulation of misfolded proteins and cell cycle arrest. It could downregulate PRR15 by disrupting the degradation processes that regulate protein levels, including those involved in cell cycle regulation. | ||||||