Profilin Activators
Profilin is a small, universally expressed protein that plays a pivotal role in the regulation of the actin cytoskeleton, a structure crucial for various cellular functions including motility, division, and signaling. This protein binds to actin monomers (G-actin) and controls the rate of actin polymerization, an essential process for the formation of actin filaments (F-actin). By binding to actin, Profilin maintains a pool of actin monomers that can be rapidly mobilized for filament assembly.
Apart from its interaction with actin, Profilin binds to phosphoinositides, particularly phosphatidylinositol 4,5-bisphosphate (PIP2), a lipid found in the plasma membrane. This binding modulates the localization of Profilin within the cell and links actin dynamics to membrane-associated signaling pathways. Profilin also interacts with proteins involved in the regulation of the actin cytoskeleton, further integrating cytoskeletal rearrangement with other cellular processes.The balance maintained by Profilin is vital for the dynamic nature of the cytoskeleton, allowing cells to rapidly respond to internal and external cues. This adaptability is essential for processes such as cell movement, the formation of cellular extensions, and the distribution of organelles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can modulate cytoskeletal dynamics and potentially increase Profilin expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may influence Profilin expression by altering actin dynamics and cell signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects cell differentiation and might regulate Profilin expression in relation to changes in the cytoskeleton. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
As a stress hormone, cortisol might influence Profilin expression in response to physiological stress and cytoskeletal changes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, could modulate Profilin expression through its effects on inflammation and cell signaling. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an inducer of oxidative stress, H2O2 may influence Profilin expression in response to changes in cellular stress. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
These can alter intracellular calcium levels, affecting Profilin expression in relation to actin dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may modulate Profilin expression through its anti-inflammatory properties and effects on cell signaling. | ||||||