PRiMA Activators
PRiMA (Proline-Rich Membrane Anchor) Activators represent a class of chemical compounds designed to modulate the activity of PRiMA proteins. PRiMA proteins are essential components of the cholinergic system, particularly in the context of acetylcholine (ACh) production and regulation. These proteins are responsible for anchoring and regulating the function of acetylcholinesterase (AChE), an enzyme critical for the termination of cholinergic signaling in the nervous system. PRiMA itself is a proline-rich, membrane-bound protein that is co-expressed with AChE in various tissues, including neurons and muscle cells.
PRiMA Activators are synthetic or natural compounds that interact with PRiMA proteins, influencing their role in AChE regulation. By modulating PRiMA activity, these activators can have a downstream impact on AChE function, affecting cholinergic signaling in the nervous system. Cholinergic signaling plays a crucial role in various physiological processes, including muscle contraction, neurotransmission, and memory formation. Therefore, understanding the role of PRiMA and the development of PRiMA Activators can provide insights into the intricacies of cholinergic neurotransmission and its relevance to neuromuscular and cognitive functions. Furthermore, PRiMA Activators may have applications in research aimed at unraveling the complexities of cholinergic signaling and its involvement in neurological disorders, without directly focusing on outcomes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May impact PRiMA expression by altering DNA methylation, potentially affecting gene transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
These can change chromatin structure, possibly leading to changes in the expression of genes including PRiMA. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Known for its role in differentiation and development, it might influence the expression of various genes, potentially including PRiMA. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a hormone, estradiol can modulate gene expression, which could affect PRiMA in hormone-responsive tissues. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid known to regulate gene expression, potentially influencing PRiMA expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing cAMP levels, forskolin can modulate gene expression pathways that might affect PRiMA expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, potentially modulating the expression of genes including PRiMA. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, it can affect chromatin and potentially regulate gene expression, including PRiMA. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Its receptor-mediated pathway might modulate gene expression, potentially affecting PRiMA. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
Known to regulate a variety of genes, it might influence PRiMA expression. | ||||||