Prickle4 Activators
Chemical activators of Prickle4 can influence its activity through various mechanisms, primarily by inhibiting Glycogen Synthase Kinase-3 (GSK-3). GSK-3 is a key enzyme that, when inhibited, leads to the activation of downstream proteins like Prickle4. Lithium Chloride, for instance, can activate Prickle4 by this inhibition, which inadvertently leads to the stabilization of Dishevelled proteins. Dishevelled proteins are pivotal in the non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway, where Prickle4 has a significant role. Similarly, SB-216763, Bio, CHIR99021, 1-Azakenpaullone, AR-A014418, Tideglusib, Indirubin-3'-monoxime, Alsterpaullone, and Paullone are all GSK-3 inhibitors that activate Prickle4. They achieve this by preventing GSK-3 from phosphorylating target proteins, thus enhancing the activity of Dishevelled proteins and promoting Wnt/PCP pathway signaling.
In addition to these GSK-3 inhibitors, Mebendazole, although primarily known for a different primary action, can also activate Prickle4 through the same GSK-3 inhibition mechanism, implying its influence on the Wnt/PCP pathway. Valproic Acid represents a slightly different mechanism; it activates Prickle4 by inhibiting histone deacetylases (HDACs). This results in hyperacetylation of proteins involved in the Wnt/PCP pathway, which can lead to an upregulation of the pathway's activity, including the function of Prickle4. Each of these chemicals, despite their differences in primary action, converge on a common pathway that results in the activation of Prickle4, highlighting the interconnected nature of cellular signaling pathways and the diverse means through which a single protein's activity can be modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can activate Prickle4 by inhibiting Glycogen Synthase Kinase-3 (GSK-3), which is involved in the non-canonical Wnt/planar cell polarity pathway where Prickle4 functions. GSK-3 inhibition leads to activation of Dishevelled (DVL) proteins, which are upstream regulators of Prickle4. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a potent GSK-3 inhibitor that can activate Prickle4 through the same pathway as Lithium Chloride, by promoting the stabilization and activation of Dishevelled proteins. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
Bio, also known as 6-Bromoindirubin-3'-oxime, is a GSK-3 inhibitor that can activate Prickle4 through stabilization of Dishevelled, thereby influencing Prickle4's role in the Wnt/PCP pathway. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 is a selective GSK-3 inhibitor that can activate Prickle4 by preventing GSK-3 mediated phosphorylation of DVL, facilitating the activation of proteins in the Wnt/PCP pathway including Prickle4. | ||||||
GSK-3β Inhibitor VIII | 487021-52-3 | sc-202636 sc-202636A | 5 mg 10 mg | $134.00 $150.00 | 5 | |
AR-A014418 is a GSK-3 inhibitor that can activate Prickle4 by enhancing the signaling activity of Dishevelled in the Wnt/PCP pathway. | ||||||
Tideglusib | 865854-05-3 | sc-507358 | 10 mg | $77.00 | ||
Tideglusib inhibits GSK-3, thereby activating Prickle4 through the enhancement of Dishevelled activity and subsequent promotion of Wnt/PCP pathway signaling. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
Indirubin-3'-monoxime is a GSK-3 inhibitor that can activate Prickle4 by stabilizing Dishevelled, which plays a crucial role in the activation of the Wnt/PCP pathway. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a GSK-3 inhibitor that activates Prickle4 by augmenting Dishevelled activity and facilitating the signaling in the Wnt/PCP pathway, which involves Prickle4. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole, while known primarily as an antiparasitic, can inhibit GSK-3 and thereby activate Prickle4 by enhancing the Wnt/PCP signaling pathway, which involves the regulation of Dishevelled proteins. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid can activate Prickle4 indirectly by inhibiting histone deacetylases (HDACs), which can lead to the hyperacetylation of proteins in the Wnt/PCP pathway, thereby potentially enhancing the function and activity of Prickle4. | ||||||