PRELI Activators
PRELI activators encompass a diverse group of compounds that can indirectly influence the function of PRELI by modulating mitochondrial biogenesis, lipid metabolism, or mitochondrial dynamics. These activators operate within various signaling pathways, invoking cellular processes that necessitate the effective transport of lipids into the mitochondria, a key function of PRELI. Compounds such as Resveratrol and SRT1720, through their activation of SIRT1, catalyze a series of events that culminate in mitochondrial biogenesis. This process demands an increased import of lipids for new mitochondrial membrane synthesis, which could enhance the activity of PRELI to facilitate this requirement. Additionally, PPAR agonists like Bezafibrate and Pioglitazone stimulate lipid metabolism pathways, which, due to their role in mitochondrial fatty acid oxidation, could indirectly increase the need for PRELI's function in transporting lipids to the mitochondria.
The augmentation of mitochondrial lipid transport may also be indirectly achieved through the actions of compounds that increase the cellular pool of NAD+, such as NAD+ itself, which subsequently influences sirtuin activity and mitochondrial function. Similarly, the activation of AMPK by molecules like Metformin and AICAR leads to the upregulation of mitochondrial biogenesis and fatty acid oxidation, processes that could signal for enhanced PRELI activity to meet the elevated lipid demand. Moreover, specific fatty acids, including Palmitoylcarnitine, and DHA, directly interact with mitochondrial lipid processing and may alter the requirements for PRELI-mediated lipid transfer, supporting the maintenance of mitochondrial lipid homeostasis. Collectively, the actions of these compounds, though not directly targeting PRELI, create cellular conditions that may upregulate PRELI activity to accommodate the changing metabolic and structural needs of the mitochondria.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can promote mitochondrial biogenesis through the activation of SIRT1 and PGC-1α. Enhanced mitochondrial biogenesis necessitates the import of lipids, potentially upregulating PRELI activity to meet the demand for new mitochondrial membrane formation. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
As a PPAR agonist, Bezafibrate stimulates the peroxisome proliferator-activated receptors, which play a role in the metabolism of lipids and can upregulate the expression of proteins involved in mitochondrial fatty acid oxidation, possibly necessitating an increase in PRELI activity to facilitate lipid transport to mitochondria. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Leptin can influence mitochondrial function through AMP-activated protein kinase (AMPK) activation. While primarily a biological molecule, synthetic analogs of Leptin affecting the AMPK pathway can lead to changes in mitochondrial dynamics and function, possibly requiring enhanced PRELI activity for lipid transport. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
As another PPAR agonist, Pioglitazone affects lipid metabolism and can increase the demand for mitochondrial lipid transport, potentially increasing the need for PRELI function. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which enhances mitochondrial biogenesis and function. This can indirectly necessitate an increase in PRELI activity to support the augmented need for lipid transport within mitochondria. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, leading to enhanced mitochondrial biogenesis and fatty acid oxidation. This increased metabolic activity may indirectly upregulate PRELI to support mitochondrial lipid homeostasis. | ||||||
Palmitoyl-L-carnitine Chloride | 18877-64-0 | sc-205789 sc-205789A sc-205789B | 5 mg 25 mg 100 mg | $138.00 $505.00 $2045.00 | ||
Palmitoylcarnitine is involved in the transport of fatty acids into mitochondria for beta-oxidation. An increase in fatty acid oxidation can enhance the requirement for PRELI's role in lipid transport. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA, like EPA, affects mitochondrial lipid composition and function. The incorporation of DHA into mitochondrial membranes may influence PRELI activity indirectly. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is an activator of SIRT1, leading to enhanced mitochondrial biogenesis. As with Resveratrol, an increase in mitochondrial biogenesis can upregulate PRELI function to support increased lipid membrane synthesis. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in various redox reactions and is a substrate for sirtuins that modulate mitochondrial function. Elevating NAD+ levels can lead to changes in mitochondrial dynamics and function, which may enhance the demand for PRELI activity. | ||||||