prefoldin 1 Activators
Prefoldin 1 Activators encompass a diverse array of chemical compounds that indirectly amplify the functional activity of Prefoldin 1 by modulating various signaling pathways and cellular processes. Forskolin, 8-Bromo-cAMP, Rolipram, and IBMX are all agents that either directly activate adenylyl cyclase or inhibit phosphodiesterases, leading to elevated intracellular cAMP levels. The increase in cAMP activates protein kinase A (PKA), which can phosphorylate a variety of substrates, potentially influencing proteins that interact with Prefoldin 1 to enhance its chaperoning role in assisting the proper folding of cytoskeletal proteins. Similarly, AICAR and Metformin are activators of AMP-activated protein kinase (AMPK), which may lead to phosphorylation events that indirectly promote Prefoldin 1's role in the assembly of protein complexes. Sirtuin activators such as Resveratrol, Nicotinamide riboside, and Piceatannol can lead to the deacetylation of proteins, which could positively impact Prefoldin 1's function by ensuring proper protein conformation and assembly.
Moreover, compounds like Spermidine and Rapamycin, which induce autophagy, could increase the requirement for Prefoldin 1's activity. Through the removal of misfolded proteins, these activators may heighten the demand for Prefoldin 1's chaperone capabilities in refolding or stabilizing newly synthesized proteins, especially during the recovery phase post-autophagy. Additionally, Lithium, by inhibiting GSK-3β, may contribute to the stabilization of the cytoskeletal infrastructure. Although not directly interacting with Prefoldin 1, this inhibition could enhance the protein's ability to support cytoskeletal protein folding by maintaining a favorable environment for its chaperone activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various substrates, potentially including those that interact with Prefoldin 1, thereby enhancing its chaperone activity for the correct folding of cytoskeletal proteins. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. By mimicking cAMP, it activates PKA, which could lead to phosphorylation events that augment the stabilizing role of Prefoldin 1 in protein folding. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown. This indirectly raises cAMP levels, subsequently activating PKA and potentially enhancing the chaperone function of Prefoldin 1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, increasing intracellular cAMP levels. This elevation of cAMP can activate PKA, which may enhance Prefoldin 1’s ability to stabilize unfolded or partially folded proteins. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can lead to downstream phosphorylation events. These phosphorylations could indirectly enhance Prefoldin 1’s role in the assembly of protein complexes. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, leading to various phosphorylation cascades that could support the function of Prefoldin 1 by stabilizing the proteins that Prefoldin 1 assists in folding. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which can lead to deacetylation of target proteins, potentially impacting Prefoldin 1’s function in maintaining proper protein structure and assembly. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a NAD+ precursor, which can enhance SIRT1 activity. Increased SIRT1 activity could favor the deacetylation of proteins that interact with Prefoldin 1, enhancing its role in protein folding. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol activates SIRT1, leading to deacetylation of proteins and potentially improving Prefoldin 1’s chaperone activity by stabilizing its substrate proteins. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy, a process that can lead to the removal of misfolded proteins, potentially increasing the demand for Prefoldin 1’s function in proper protein folding. | ||||||