PRAS40 Inhibitors
PRAS40 inhibitors belong to a distinct chemical class that primarily targets the proline-rich Akt substrate 40 kDa (PRAS40) protein, a crucial component of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. This signaling cascade plays a pivotal role in regulating cell survival, growth, and metabolism, making PRAS40 a noteworthy node within this intricate network. PRAS40 itself serves as a negative regulator of Akt signaling by inhibiting the phosphorylation and activation of Akt. The inhibition of PRAS40, therefore, has significant implications for modulating the cellular response to various external stimuli and maintaining cellular homeostasis.
PRAS40 inhibitors are designed to selectively interact with PRAS40, disrupting its normal function within the PI3K/Akt pathway. By doing so, these inhibitors can exert a downstream impact on cellular processes influenced by Akt activation. The development of PRAS40 inhibitors involves a meticulous understanding of the structural features of PRAS40 and the molecular interactions that govern its activity. Researchers employ various drug discovery techniques, including computational modeling, high-throughput screening, and structural biology, to design and optimize molecules with high affinity and specificity for PRAS40. This chemical class represents a promising avenue for further elucidating the intricacies of the PI3K/Akt signaling pathway and exploring potential avenues for manipulating cellular responses in a controlled manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, rapamycin can suppress mTORC1 activity, thereby reducing the phosphorylation and activity of PRAS40. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
A selective mTOR inhibitor that can inhibit both mTORC1 and mTORC2, indirectly reducing PRAS40 activity by altering downstream signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, LY294002 can decrease Akt phosphorylation, consequently affecting PRAS40 activity which is regulated by Akt. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that can lead to reduced Akt activation and thereby influence PRAS40's interaction with the mTORC1 complex. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
An Akt inhibitor that can decrease PRAS40 phosphorylation by inhibiting Akt, which is upstream of PRAS40 in the signaling pathway. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
A highly selective inhibitor of Akt, MK-2206 can modulate PRAS40 activity indirectly through the Akt pathway. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
A dual TORC1/TORC2 inhibitor, which could affect PRAS40 activity by modulating its interaction with the mTOR complexes. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
A selective mTOR kinase inhibitor, PP242 can inhibit both mTORC1 and mTORC2, potentially affecting PRAS40 function. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
An inhibitor of mTOR, Ku-0063794 can suppress mTORC1 and mTORC2, thereby influencing PRAS40 activity by altering mTOR signaling. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
A potent and selective mTOR inhibitor, AZD8055 can impact PRAS40 activity by inhibiting downstream signaling processes that involve mTORC1 and mTORC2. | ||||||