Pragmin Activators
Pragmin, also known as "Echinoderm microtubule-associated protein-like 4" (EML4), is a protein that is encoded by the EML4 gene in humans. It is a member of the echinoderm microtubule-associated protein-like family and is implicated in the regulation of microtubule dynamics. Pragmin is involved in various cellular processes, including cell division, cell signaling, and the maintenance of cell shape and intracellular transport.The protein contains an N-terminal basic region that is responsible for microtubule binding and a C-terminal WD repeat domain, a structural motif that is involved in protein-protein interactions. Pragmin's ability to associate with microtubules suggests it plays a role in the stabilization of these cytoskeletal elements and the proper formation of the mitotic spindle during cell division.
Pragmin has been studied extensively for its role in the pathogenesis of non-small cell lung cancer (NSCLC). The EML4 gene can form a fusion with the anaplastic lymphoma kinase (ALK) gene, resulting in the EML4-ALK fusion protein. This fusion protein is an oncogenic driver in a subset of NSCLC cases, leading to uncontrolled cell growth and survival. Moreover, Pragmin is thought to be involved in signal transduction pathways, mediating cellular responses to external stimuli. Its interaction with microtubules suggests a potential role in intracellular signaling and trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, could indirectly influence Pragmin by modulating tyrosine kinase-dependent signaling pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2, another tyrosine kinase inhibitor, might affect Pragmin activity indirectly by altering signaling pathways that involve tyrosine phosphorylation. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a broad-spectrum tyrosine kinase inhibitor, could have an indirect impact on Pragmin through its effects on various tyrosine kinases. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, known for its influence on multiple signaling pathways, might indirectly affect Pragmin activity, particularly if it's involved in kinase-regulated pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, with its wide-ranging effects on cell signaling, could indirectly impact Pragmin activity if it's involved in pathways influenced by inflammation or oxidative stress. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY294002 could indirectly influence Pragmin activity by modulating PI3K/Akt signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a potent kinase inhibitor, might affect Pragmin indirectly due to its broad inhibitory effects on various kinases. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects gene expression and signaling pathways, potentially impacting Pragmin activity if linked to these mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can alter cellular pathways, potentially influencing Pragmin activity if it's involved in pathways regulated by mTOR. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, could indirectly affect Pragmin through its role in modulating JNK-mediated signaling pathways. | ||||||