PPIL4 Activators
Chemical activators of PPIL4 can engage in various interactions to facilitate the protein's peptidyl-prolyl isomerase activity, which is central to its role in protein folding. Cyclosporin A, Alisporivir, and Sanglifehrin A, by virtue of their affinity for cyclophilins, can bind to PPIL4. This binding can activate PPIL4's isomerase activity, as these chemicals are known to interact with and activate proteins that share functional similarities with PPIL4. Similarly, FK506 and Rapamycin, which target the FKBP family of proteins, can bind to and activate PPIL4 due to the structural and functional parallels between these proteins. This activation can enhance the protein's ability to assist in the proper folding and function of other cellular proteins.
Further, chemicals like Meleagrin, though not directly linked to the cyclophilin family, can still activate PPIL4 through their known interactions with cyclophilins, suggesting a possible overlap in binding and activation mechanisms. Quercetin, through its capacity to influence protein-protein interactions, can engage PPIL4 in a manner that promotes its interaction with substrate proteins. Geldanamycin and Withaferin A, by affecting the protein chaperone network, can create a demand for PPIL4 activity, thereby activating it to maintain protein homeostasis. Moreover, Ribociclib's role in cell cycle progression can necessitate an increase in PPIL4 activity, as proper protein folding is crucial during cell division. Lastly, Epigallocatechin gallate's influence on the proteostasis network can activate PPIL4, ensuring that its isomerization function is available to assist in the complex process of protein folding and maintenance within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A binds to cyclophilins and inhibits their peptidyl-prolyl isomerase activity. Because PPIL4 has peptidyl-prolyl isomerase activity, Cyclosporin A binding to PPIL4 would result in activation of its isomerase activity by preventing its inhibition. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 binds to FK-binding proteins (FKBP) family, which shares the peptidyl-prolyl isomerase activity with PPIL4. The binding to similar proteins suggests that FK506 could bind to PPIL4, enhancing its protein folding activity within cellular pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to FKBP12, a member of the FKBP family with similarities to PPIL4. Its binding could suggest an activation potential for PPIL4, promoting its role in protein folding and maturation. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
Ribociclib, a cyclin-dependent kinase inhibitor, can alter cell cycle progression. By affecting the cell cycle, it could increase the demand for PPIL4 activity in protein folding necessary for cell cycle progression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid with various cellular effects, can also influence protein-protein interactions. It could activate PPIL4 by promoting its interaction with substrates or other proteins requiring isomerization. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, affecting its function. By altering the chaperone network, it could create a cellular environment where PPIL4 activity is upregulated to meet increased protein folding demands. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A disrupts proteasomal activity, potentially leading to increased misfolded protein levels. This could activate PPIL4 as a compensatory mechanism to aid in refolding proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate has been shown to influence the folding of specific proteins. It could activate PPIL4 by altering the proteostasis network, thus enhancing the protein's isomerization and folding functions. | ||||||