PPIAL4 Activators
PPIAL4 Activators refers to a specific category of chemical compounds or molecules that have gained recognition and interest within the field of molecular biology and cellular research. These activators are designed or discovered to selectively modulate the activity of the PPIAL4 gene. PPIAL4, or Peptidylprolyl Isomerase A Like 4, is a protein-coding gene found in humans and other organisms. It encodes for a peptidylprolyl isomerase enzyme that is known to play a role in facilitating protein folding and post-translational modifications, which are essential processes in cellular homeostasis and the proper functioning of various cellular components.
PPIAL4 activators have garnered attention due to their potential to influence the expression or function of the PPIAL4 gene, thus enabling researchers to explore the gene's specific role in cellular physiology and molecular mechanisms. By activating PPIAL4, scientists aim to better understand the intricate pathways and cellular processes that rely on the enzymatic activity of this gene product. This knowledge can contribute to the broader understanding of cellular dynamics, protein stability, and protein-protein interactions within cells, shedding light on the fundamental principles governing gene regulation and cellular behavior. As such, PPIAL4 activators represent valuable tools for researchers striving to unravel the complexities of molecular biology and the critical roles of specific genes in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
May induce heat shock response, leading to the upregulation of chaperones and isomerases to manage misfolded proteins. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
A Hsp90 inhibitor that can activate heat shock factor 1 (HSF1), potentially increasing the expression of chaperones and isomerases. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress and the unfolded protein response, potentially increasing demand for protein folding enzymes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that causes protein accumulation, possibly upregulating chaperones and isomerases to restore proteostasis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Another proteasome inhibitor, which might similarly lead to increased expression of protein folding machinery due to proteostasis disruption. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Triggers ER stress by inhibiting the SERCA pump, potentially enhancing expression of proteins involved in the unfolded protein response. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Acts as a chemical chaperone, potentially upregulating genes involved in protein folding and stress responses. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to induce autophagy inhibition, potentially leading to cellular stress and upregulation of chaperones and isomerases. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can induce autophagy and might affect the expression of genes involved in protein folding and degradation. | ||||||