PPAR alpha Activators
Items 21 to 30 of 44 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auraptene | 495-02-3 | sc-202477 sc-202477A | 5 mg 25 mg | $45.00 $60.00 | ||
Auraptene acts as a PPAR alpha modulator, distinguished by its capacity to form unique π-π stacking interactions with the receptor's ligand-binding domain. This compound demonstrates a remarkable ability to induce conformational changes, facilitating the recruitment of coactivators and enhancing transcriptional regulation. Its influence on metabolic pathways is evident through the modulation of genes involved in lipid catabolism and energy expenditure, contributing to metabolic regulation. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $37.00 $113.00 | 2 | |
Activates PPARα by direct binding, affecting lipid metabolism. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
An older fibrate that directly binds to PPARα to induce its activation. | ||||||
Ciprofibrate | 52214-84-3 | sc-204689 sc-204689A | 25 mg 100 mg | $57.00 $169.00 | ||
Ciprofibrate functions as a PPAR alpha agonist, characterized by its ability to engage in hydrophobic interactions within the receptor's binding pocket. This compound promotes the dimerization of PPAR alpha with retinoid X receptor (RXR), leading to enhanced transcriptional activity. Its kinetic profile reveals a rapid onset of action, influencing lipid metabolism by upregulating genes associated with fatty acid oxidation and triglyceride clearance, thereby impacting overall metabolic homeostasis. | ||||||
13-OxoODE | 54739-30-9 | sc-204993 sc-204993A | 25 µg 50 µg | $163.00 $306.00 | ||
13-OxoODE acts as a PPAR alpha ligand, exhibiting unique binding dynamics that facilitate conformational changes in the receptor. This compound selectively modulates gene expression linked to lipid metabolism by promoting the recruitment of coactivators. Its interaction with PPAR alpha enhances the transcription of genes involved in fatty acid transport and oxidation, contributing to metabolic regulation. The compound's stability and reactivity in biological systems further influence its signaling pathways. | ||||||
PGJ2 (Prostaglandin J2) | 60203-57-8 | sc-201248 sc-201248A sc-201248B sc-201248C sc-201248D | 1 mg 10 mg 50 mg 100 mg 500 mg | $224.00 $1821.00 $9000.00 $13500.00 $63300.00 | ||
PGJ2 serves as a potent PPAR alpha ligand, engaging in specific molecular interactions that trigger receptor activation. Its unique structure allows for selective binding, leading to significant alterations in receptor conformation. This interaction promotes the expression of genes associated with lipid homeostasis and energy expenditure. Additionally, PGJ2's reactivity with cellular components can modulate inflammatory pathways, highlighting its role in metabolic signaling networks. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Though primarily a PPARγ agonist, also shows some affinity for PPARα. | ||||||
LY 171883 | 88107-10-2 | sc-203120 | 10 mg | $72.00 | ||
LY 171883 acts as a selective PPAR alpha agonist, exhibiting unique binding characteristics that enhance receptor affinity. Its distinct molecular architecture facilitates the stabilization of the receptor's active conformation, promoting downstream signaling cascades. This compound influences lipid metabolism and fatty acid oxidation through specific gene regulation. Furthermore, LY 171883's interaction with coactivators and corepressors fine-tunes metabolic pathways, underscoring its role in cellular energy regulation. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
A long-chain polyunsaturated fatty acid that activates PPARα. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone functions as a selective PPAR alpha modulator, characterized by its ability to engage in specific hydrogen bonding interactions with the receptor's ligand-binding domain. This interaction promotes conformational changes that enhance receptor activity, leading to the modulation of gene expression involved in lipid homeostasis. Additionally, Pioglitazone's unique structural features allow it to selectively influence metabolic pathways, impacting fatty acid transport and oxidation processes at a cellular level. | ||||||