Molecular structure of LY 171883, CAS Number: 88107-10-2
LY 171883 (CAS 88107-10-2)
Application:
LY 171883 is a selective leukotriene D4 antagonist
CAS Number:
88107-10-2
Molecular Weight:
318.4
Molecular Formula:
C16H22N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 171883, a CysLT1 Receptor (leukotriene D4) antagonist, has been shown to displace oleic acid (sc-200797) binding to fatty-acid-binding protein (FABP) which may be involved in fatty acid metabolism. Studies suggest that this compound contains structural similarity to fatty acids, hence the ability to bind to FABPs. Additional data suggests that LY 171883 causes membrane hyperpolarization and reduces firing rate of action potentials in neuroblastoma cells in vitro. LY 171883 is an inhibitor of PDE and an activator of PPAR α and PPAR γ.
LY 171883 (CAS 88107-10-2) References
- Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | Li, PC., et al. 2002. J Cell Physiol. 192: 188-99. PMID: 12115725
- Leukotrienes mediate 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint via CysLT-type receptors. | Wang, Y., et al. 2004. Inflamm Res. 53: 66-71. PMID: 15021971
- Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. | Cannon, JR. and Eacho, PI. 1991. Biochem J. 280 (Pt 2): 387-91. PMID: 1747111
- Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats. | Park, SJ., et al. 2011. Br J Anaesth. 106: 31-7. PMID: 20935003
- Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts. | Jolly, SR., et al. 1989. Pharmacology. 38: 352-62. PMID: 2813496
- Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615. | Aharony, D., et al. 1987. J Pharmacol Exp Ther. 243: 921-6. PMID: 2826761
- Stimulation of thromboxane release by extracellular UTP and ATP from perfused rat liver. Role of icosanoids in mediating the nucleotide responses. | Häussinger, D., et al. 1988. Eur J Biochem. 178: 249-56. PMID: 2849542
- Systemic and regional hemodynamic effects of leukotrienes D4 and E4 in the conscious rat. | Eimerl, J., et al. 1986. Am J Physiol. 251: H700-9. PMID: 3021000
- LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist. | Fleisch, JH., et al. 1985. J Pharmacol Exp Ther. 233: 148-57. PMID: 3981452
- Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | Kliewer, SA., et al. 1994. Proc Natl Acad Sci U S A. 91: 7355-9. PMID: 8041794
Inhibitor of:
CysLT1 Receptor, and PDE.Activator of:
PPAR alpha, and PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 171883, 10 mg | sc-203120 | 10 mg | $72.00 |