PP2B-Aβ Inhibitors
The chemical class of PP2B-Aβ inhibitors comprises a diverse array of compounds that influence the activity of the PP2B-Aβ protein complex through various mechanisms. These inhibitors work by directly binding to PP2B-Aβ or its associated proteins, or indirectly by modulating related signaling pathways and cellular processes. The inhibition of PP2B-Aβ by these compounds reflects the complex nature of cellular regulation and the potential of chemical entities to modulate protein activity through both direct and indirect means.
Some compounds, such as Cyclosporin A and FK506, exhibit a direct inhibitory effect on PP2B-Aβ by forming complexes that inhibit its phosphatase activity. Others, like Rapamycin, exert an indirect influence through their primary targets in other signaling pathways, which in turn affect PP2B-Aβ. The dual nature of compounds like Okadaic Acid and Calyculin A, serving as activators at low concentrations and inhibitors at higher concentrations, highlights the delicate balance of phosphatase activities within the cell. Additionally, compounds like Phenylarsine Oxide and Sodium Fluoride inhibit PP2B-Aβ through their effects on redox-sensitive mechanisms and general phosphatase inhibition, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A binds to cyclophilin, forming a complex that inhibits the phosphatase activity of PP2B-Aβ, leading to its direct inhibition. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 binds to FKBP12, creating a complex that inhibits PP2B-Aβ. This inhibition is direct and specific to the PP2B-Aβ phosphatase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
While primarily an mTOR inhibitor, Rapamycin also binds to FKBP12 but does not inhibit PP2B-Aβ directly. Its influence on mTOR pathways can indirectly modulate PP2B-Aβ activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Although a potent activator of PP2B-Aβ at low concentrations, at higher concentrations, Okadaic Acid can inhibit PP2B-Aβ by affecting the overall balance of phosphatase activities. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to Okadaic Acid, Calyculin A at higher concentrations can inhibit PP2B-Aβ by disrupting the phosphatase activity balance within the cell. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
By binding to vicinal dithiols, Phenylarsine Oxide can indirectly inhibit PP2B-Aβ activity, affecting its redox-sensitive regulatory mechanisms. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium Fluoride is a general inhibitor of phosphatases, including PP2B-Aβ, and can reduce its activity by altering the phosphate groups in the protein. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $49.00 $203.00 | 1 | |
Endothall acts as an inhibitor of PP2B-Aβ by mimicking the transition state of phosphate ester hydrolysis, thereby reducing PP2B-Aβ's phosphatase activity. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is a potent inhibitor of serine/threonine phosphatases, including PP2B-Aβ, reducing its activity by binding to the catalytic subunit. | ||||||
Sodium metavanadate | 13718-26-8 | sc-251034 sc-251034A | 5 g 25 g | $32.00 $84.00 | 3 | |
Vanadate is a transition-state analog for phosphate ester hydrolysis, inhibiting various phosphatases including PP2B-Aβ by mimicking the phosphorylated substrate. | ||||||