POSH Activators
POSH activators comprise a specialized group of chemical entities that target the protein Plenty of SH3s (POSH), which is a scaffolding protein involved in the assembly of multi-protein complexes that participate in signaling pathways leading to Jun N-terminal kinase (JNK) activation. POSH is thought to facilitate the propagation of signals that result in programmed cell death, also known as apoptosis, through its role in JNK activation.
The activation of POSH by direct activators would presumably involve the interaction of these chemicals with specific domains within the POSH protein that are crucial for its scaffolding function. Such interactions might enhance POSH's ability to recruit and organize the proteins necessary for the effective activation of JNK, for instance, by inducing conformational changes that increase the affinity of POSH for its binding partners or by stabilizing the formation of the signaling complexes. Indirect activators of POSH might work by upregulating the expression of the POSH gene, thus increasing the amount of protein available for complex formation. Alternatively, they might inhibit the degradation of POSH, leading to an accumulation of functional POSH within the cell. They could also act on parallel signaling pathways that modulate the activity of POSH or its partners through post-translational modifications such as phosphorylation, ubiquitination, or sumoylation, which might alter its ability to engage in protein-protein interactions or change its cellular localization.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analogue that activates PKA. POSH acts downstream of Rac1, a small GTPase. PKA can phosphorylate Rac1, leading to its activation. The activated Rac1 can then enhance the functional activity of POSH. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, which is known to inhibit Rac1. By inhibiting ROCK, Y-27632 can enhance Rac1 activity, which in turn can enhance the functional activity of POSH. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 is an inhibitor of Rac1-specific GEFs such as Tiam1. By inhibiting Tiam1, NSC 23766 allows more Rac1 to be available for other GEFs, potentially enhancing Rac1 activation and indirectly enhancing POSH activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels and activates Protein Kinase A (PKA), which can phosphorylate and activate Rac1. The activated Rac1 can then enhance the functional activity of POSH. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC) which can phosphorylate and activate Rac1. The activated Rac1 can then enhance the functional activity of POSH. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a GSK3 inhibitor. GSK3 can inhibit Rac1, so by inhibiting GSK3, Lithium Chloride can enhance Rac1 activity, which in turn can enhance the functional activity of POSH. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is a stabilizer of actin filaments. Rac1 is involved in actin cytoskeleton rearrangement. By stabilizing actin filaments, Jasplakinolide can enhance Rac1 activity, which in turn can enhance the functional activity of POSH. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK1 which can inhibit ERK1/2. ERK1/2 can inhibit Rac1, so by inhibiting MEK1, PD98059 can enhance Rac1 activity, which in turn can enhance the functional activity of POSH. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a Rac1 inhibitor. However, it acts by locking Rac1 in an inactive state, which can lead to compensatory mechanisms in the cell that increase the activity of other Rac1 molecules, potentially enhancing POSH activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K can inhibit Rac1, so by inhibiting PI3K, LY294002 can enhance Rac1 activity, which in turn can enhance the functional activity of POSH. | ||||||