POPX1 Inhibitors
POPX1 inhibitors constitute a class of compounds that modulate the activity of POPX1, an essential regulator within the intricate Wnt/β-catenin signaling pathway. These inhibitors, such as ITX3, TWS119, KY02111, XAV939, CHIR-99021, IWR-1, CCT036477, JW67, BIO, ICG-001, G007-LK, and CCT031374, act either directly or indirectly to influence POPX1 function, offering potential avenues for interventions. Indirect POPX1 inhibitors, like ITX3, TWS119, and KY02111, target tankyrase, a key player in the degradation of Axin1. By disrupting this process, these inhibitors prevent the degradation of β-catenin, stabilizing its levels within the cell. Similarly, compounds such as XAV939, IWR-1, CCT036477, JW67, G007-LK, and CCT031374 exert their indirect inhibition by interfering with tankyrase activity, leading to increased β-catenin degradation. This modulation of the Wnt/β-catenin pathway indirectly impacts POPX1, influencing cellular processes reliant on proper Wnt signaling.
Direct inhibitors, including CHIR-99021, BIO, and ICG-001, target GSK-3β and CREB-binding protein (CBP)/β-catenin, respectively. By inhibiting GSK-3β, CHIR-99021 and BIO stabilize β-catenin, preventing its degradation and indirectly affecting POPX1 activity. On the other hand, ICG-001 directly inhibits the transcriptional activity of β-catenin, impacting cellular processes that involve POPX1 within the Wnt signaling cascade. In conclusion, the diverse mechanisms of action exhibited by POPX1 inhibitors provide a rich landscape for further exploration and understanding of the intricate regulatory networks governing Wnt/β-catenin signaling. These inhibitors present valuable tools for unraveling the nuanced interactions within this pathway and hold promise for potential applications in conditions where dysregulation of POPX1 is implicated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
ITX3 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, ITX3 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, KY02111 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, XAV939 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR-99021 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a GSK-3β inhibitor, CHIR-99021 stabilizes β-catenin, preventing its degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, IWR-1 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
CCT036477 | 305372-78-5 | sc-391631A sc-391631 | 5 mg 25 mg | $107.00 $428.00 | 1 | |
CCT036477 inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, CCT036477 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a GSK-3β inhibitor, BIO stabilizes β-catenin, preventing its degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
G007-LK | 1380672-07-0 | sc-507467 | 1 mg | $48.00 | ||
G007-LK inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, G007-LK disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||
1-[1,1′-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide | 1219184-91-4 | sc-503576 | 10 mg | $360.00 | ||
1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide inhibits POPX1 indirectly by targeting the Wnt/β-catenin signaling pathway. As a tankyrase inhibitor, CCT031374 disrupts the degradation of Axin1, leading to increased β-catenin degradation. This indirect inhibition modulates POPX1, impacting cellular processes dependent on proper Wnt/β-catenin signaling. | ||||||