Molecular structure of G007-LK, CAS Number: 1380672-07-0
G007-LK (CAS 1380672-07-0)
Alternate Names:
Tankyrase 1/2 Inhibitor VI; 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-benzonitrile
CAS Number:
1380672-07-0
Molecular Weight:
530.0
Molecular Formula:
C25H16ClN7O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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G007-LK (CAS 1380672-07-0) References
- Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. | Voronkov, A., et al. 2013. J Med Chem. 56: 3012-23. PMID: 23473363
- The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. | Norum, JH., et al. 2018. Biol Res. 51: 3. PMID: 29316982
- Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. | Mygland, L., et al. 2021. iScience. 24: 102807. PMID: 34337362
- TNKS inhibitors potentiate proliferative inhibition of BET inhibitors via reducing β-Catenin in colorectal cancer cells. | Wu, Q., et al. 2022. Am J Cancer Res. 12: 1069-1087. PMID: 35411247
- Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation-driven hepatocarcinogenesis. | Liang, B., et al. 2023. Hepatology. 77: 1929-1942. PMID: 35921500
- Phosphorylation of axin within biomolecular condensates counteracts its tankyrase-mediated degradation. | Klement, K., et al. 2023. J Cell Sci. 136: PMID: 37721093
- A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors. | Tse, J., et al. 2023. Biomedicines. 11: PMID: 37893093
- APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells. | Chen, M., et al. 2024. Br J Cancer. 130: 151-162. PMID: 37968472
- A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer. | Zhu, H., et al. 2024. Acta Pharm Sin B. 14: 207-222. PMID: 38261825
- 3D layered co-culture model enhances Trastuzumab Deruxtecan sensitivity and reveals the combined effect with G007-LK in HER2-positive non-small cell lung cancer. | Shiraishi, A., et al. 2024. Biochem Biophys Res Commun. 725: 150255. PMID: 38897043
Inhibitor of:
β-catenin, APC, Axin, brachyury 2, DNA pol κ, P-cadherin, POPX1, Shelterin complex, Tankyrase, Tankyrase-1, Tankyrase-2, TBL1XR1, TCF-3, and Zfp866.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
G007-LK, 1 mg | sc-507467 | 1 mg | $48.00 |