POP2 Inhibitors
POP2 (Pyrin-Only Protein 2) inhibitors represent a niche category in the realm of molecular chemistry, focusing on regulating the activity of the POP2 protein. The primary function of POP2, a member of the Pyrin-Only Protein family, is its role in modulating inflammation processes within the cellular environment. By targeting the NLRP3 inflammasome, POP2 inhibits the activation and maturation of pro-inflammatory cytokines, which are pivotal players in inflammatory pathways. Inflammasomes are multi-protein complexes that recognize various pathogenic and stress signals, leading to the activation of caspase-1, which subsequently processes pro-inflammatory cytokines like IL-1β and IL-18 into their mature forms. POP2 achieves this inhibitory function by binding directly to NLRP3, blocking its activation and assembly.
Inhibitors targeting POP2 serve to modulate this pathway by either blocking POP2's binding to NLRP3 or by interfering with its expression or stability. The molecular mechanisms underlying these inhibitors are diverse, often focusing on structural interactions and conformational changes that limit POP2's functional efficacy. Given the protein-protein interaction nature of the POP2-NLRP3 relationship, small molecule inhibitors would typically aim at destabilizing this association, thus allowing NLRP3 inflammasome to proceed with its activation. Other inhibitors might function by modulating the post-translational modifications of POP2, which could play a role in its binding efficiency or stability. Understanding the nuances of POP2's interaction with the NLRP3 inflammasome and devising molecules that can effectively interfere with this interaction is central to the science behind POP2 inhibitors. The intricate dance between inflammatory signals, modulatory proteins, and their respective inhibitors underscores the complex web of cellular regulation and the myriad ways it can be influenced.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is a potent and irreversible inhibitor of cysteine proteases. It acts by binding covalently to the active site thiol of cysteine proteases, thus blocking the substrate access and inhibiting enzyme activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is an inhibitor of serine and cysteine proteases. It acts by forming a reversible bond with the thiol group of the active site cysteine. | ||||||
Odanacatib | 603139-19-1 | sc-364675 sc-364675A sc-364675B | 5 mg 25 mg 250 mg | $214.00 $974.00 $1943.00 | 2 | |
Designed to inhibit cathepsin K, a cysteine protease involved in osteoclast-mediated bone resorption. Odanacatib binds to the active site of the enzyme, blocking substrate interaction. | ||||||
Z-FA-FMK | 197855-65-5 | sc-201303 sc-201303A | 1 mg 5 mg | $125.00 $365.00 | 19 | |
This is a cell-permeable and irreversible inhibitor of cysteine proteases. It acts by targeting the active cysteine residue in the active site of the enzyme. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
A broad-spectrum caspase inhibitor. It is a fluoromethyl ketone that covalently binds to the active site cysteine of caspases, inhibiting their protease activity. | ||||||
CA-074 | 134448-10-5 | sc-202513 | 1 mg | $315.00 | ||
A selective inhibitor for cathepsin B, a cysteine protease. It interacts with the active site, particularly with the thiol group of the enzyme's cysteine, thereby inhibiting its activity. | ||||||
K777 | 233277-99-1 | sc-507382 | 10 mg | $555.00 | ||
Targets cruzain, the major cysteine protease of Trypanosoma cruzi. It binds covalently to the active site, thus blocking the enzyme's activity. | ||||||