POP2 Activators
Pyrin domain containing 2 (NLRP2), also known as NACHT, LRR, and PYD domains-containing protein 2, is part of the NOD-like receptor (NLR) family. This family of proteins plays a significant role in the innate immune system, primarily in the regulation of inflammation and apoptosis. NLRP2 is characterized by the presence of a pyrin domain, which is involved in protein-protein interactions, particularly in the formation of inflammasomes.
Inflammasomes are multi-protein complexes that play a critical role in the immune system. They are responsible for the activation of pro-inflammatory cytokines like IL-1β and IL-18, which are crucial in the body's response to infection and injury. NLRP2, through its involvement in inflammasome formation, helps in detecting pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). This detection triggers a cascade of immune responses aimed at protecting the body against infections and responding to cellular stress.The specific functions of NLRP2 are not as well characterized as some other NLR proteins, but it is believed to be involved in the regulation of both innate and adaptive immune responses. Variations in the NLRP2 gene have been associated with various reproductive and inflammatory disorders, suggesting its importance in physiological as well as pathological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a component of bacterial cell walls, may induce NLRP2 as part of the innate immune response to bacterial infection. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C), a synthetic analog of double-stranded RNA, could upregulate NLRP2 in response to viral infections. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
Extracellular ATP, signaling cellular stress or damage, could potentially enhance NLRP2 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc, an essential trace element, may influence NLRP2 expression due to its role in immune function and cell signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may modulate NLRP2 expression through its anti-inflammatory properties and effects on cellular signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might affect NLRP2 expression due to its role in modulating inflammation and oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, could influence NLRP2 expression through its detoxifying and antioxidant effects. | ||||||