Molecular structure of CA-074, CAS Number: 134448-10-5
CA-074 (CAS 134448-10-5)
Alternate Names:
N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline; L-Proline, 1-(N-((3-((propylamino)carbonyl)oxiranyl)carbonyl)-L-isoleucyl)-, (2S-trans)-
Application:
CA-074 is a potent and specific inhibitor of cathepsin B in vitro
CAS Number:
134448-10-5
Molecular Weight:
383.44
Molecular Formula:
C18H29N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CA-074 is a potent and specific inhibitor of cathepsin B. CA-074 is known for the inhibition of the enzyme acetylcholinesterase and the activation of caspase-3. It has also been studied for its potential to modulate the activity of certain proteins, such as the transcription factor NF-κB.
CA-074 (CAS 134448-10-5) References
- Inhibitory effect of cathepsin B inhibitor CA 074 on mouse anti-rat mixed lymphocyte reaction: novel immunosuppressive strategy for indirect xenoantigen recognition. | Tohyama, T., et al. 2000. Transplant Proc. 32: 944-5. PMID: 10936287
- CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. | Montaser, M., et al. 2002. Biol Chem. 383: 1305-8. PMID: 12437121
- Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. | Towatari, T., et al. 1991. FEBS Lett. 280: 311-5. PMID: 2013329
- Cathepsin B inhibition limits bone metastasis in breast cancer. | Withana, NP., et al. 2012. Cancer Res. 72: 1199-209. PMID: 22266111
- CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. | Patel, N., et al. 2015. J Orthop Res. 33: 1474-86. PMID: 25428830
- HIV-infected microglia mediate cathepsin B-induced neurotoxicity. | Zenón, F., et al. 2015. J Neurovirol. 21: 544-58. PMID: 26092112
- Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation. | Tang, Y., et al. 2018. J Physiol Biochem. 74: 503-510. PMID: 30019185
- The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes. | Oberstein, TJ., et al. 2020. Front Mol Neurosci. 13: 615740. PMID: 33510618
- Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis. | Ansari, MA., et al. 2022. Exp Neurol. 351: 113997. PMID: 35122866
- Cathepsin-B inhibitor CA-074 attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced in SJL/J mice. | Rashid Khan, M., et al. 2023. Saudi Pharm J. 31: 147-153. PMID: 36685301
- Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue. | Werle, B., et al. 1995. Biol Chem Hoppe Seyler. 376: 157-64. PMID: 7612192
- Specific assay method for the activities of cathepsin L-type cysteine proteinases. | Inubushi, T., et al. 1994. J Biochem. 116: 282-4. PMID: 7822244
- Participation of cathepsin L on bone resorption. | Kakegawa, H., et al. 1993. FEBS Lett. 321: 247-50. PMID: 8477857
- Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. | Yamashima, T., et al. 1998. Eur J Neurosci. 10: 1723-33. PMID: 9751144
Inhibitor of:
2310051M13Rik, 8030411F24Rik, Cathepsin, cathepsin 8, cathepsin A, cathepsin B, cathepsin C, cathepsin J, cathepsin M, cathepsin Q, Chymostatin, CST, Cst9, CTLA-2α, cystatin B, cystatin C, Cystatin D, cystatin E/M, EG433016, gasdermin, granzyme D, LAMP-2, LAPTM4A, Legumain, mCST E2, NALP14, PC-LKC, PJA2, POP2, Protease, SLC25A14, SLC25A41, stefin A2l1, stefin A3L1, TIP47, and Vrho.Activator of:
ACTA1, ADAM8, cathepsin J, EG433016, and Ocathepsin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA-074, 1 mg | sc-202513 | 1 mg | $315.00 |