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Hi, I am going to use this drug to inhibit Cathepsin K in my cell of interest. Could you tell me how to make (reconstitute) stock soln? Is this soluble in water? or, DMSO? MeOH? Thank you for your help!
Asked by: Tatapi
Thank you for your question. Odanacatib (CAS 603139-19-1) sc-364675 is reported to be soluble in DMSO and slightly in Chloroform and Methanol. Sonication may be needed for the latter two solvents and solutions should be prepared fresh. Stock solutions in DMSO may be stored at +4 °C for short term storage or at -20 °C for long term storage.
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Schultz et alSchultz et al. (PubMed ID 26344800) found that Odanacatib inhibited cathepsin K and reduced bone absorption while also preserving bone formation in women with postmenopausal osteoporosis. -SCBT Publication Review
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