POMT2 Activators
POMT2 activators are a category of compounds that focus on modulating the activity of Protein O-Mannosyltransferase 2 (POMT2), an enzyme that plays a pivotal role in the post-translational modification of proteins through O-mannosylation. This modification is essential for the proper function of a subset of proteins, particularly those involved in cellular structure and signaling. POMT2 works in tandem with POMT1 as part of a complex to catalyze the transfer of mannose to serine or threonine residues on target proteins, a process critical for the maturation and functionality of a variety of proteins, including α-dystroglycan, which is key for muscle and neuronal function.
Activators of POMT2 can directly or indirectly increase the enzymatic activity of POMT2. Direct activators may bind to the POMT2 enzyme, stabilizing it in an active conformation or enhancing its affinity for its substrates, which can lead to an increased rate of O-mannosylation reactions. These activators could mimic the natural substrates of POMT2 or bind to allosteric sites that promote the enzyme's catalytic action. Indirect activators may influence the expression and function of POMT2 through a variety of mechanisms. They might upregulate the transcription of the POMT2 gene or increase the stability of its mRNA, thereby elevating the levels of POMT2 protein available for enzymatic action. Alternatively, they could affect the folding and post-translational modifications of POMT2 required for its activity or influence the formation of the POMT1-POMT2 complex, essential for its function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Mannose | 3458-28-4 | sc-211180 sc-211180A | 100 g 250 g | $101.00 $158.00 | 1 | |
Mannose is an essential sugar molecule that is transferred to proteins during O-mannosylation, a process wherein POMT2 plays a critical role. Increased availability of Mannose can enhance the glycosylation activity of POMT2. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $92.00 $159.00 $300.00 | 1 | |
N-Acetylglucosamine is another sugar molecule that forms part of the glycan structures transferred during glycosylation, a process directly involving POMT2. Hence, increased levels of GlcNAc can enhance POMT2's functional activity. | ||||||
GDP-D-mannose | 3123-67-9 | sc-285856B sc-285856C sc-285856 sc-285856A sc-285856D | 5 mg 10 mg 25 mg 50 mg 100 mg | $175.00 $200.00 $430.00 $775.00 $1175.00 | ||
GDP-Mannose is the activated form of mannose that is used in mannosylation. Increased levels of GDP-Mannose could boost the activity of POMT2. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, thus potentially increasing the availability of substrates for O-mannosylation, the specific type of glycosylation that POMT2 is involved in, potentially enhancing its function. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is a solvent that can enhance the permeability of cellular membranes, potentially facilitating the transport of glycosylation substrates or products, and indirectly enhancing POMT2's function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases cAMP levels and activates Protein Kinase A (PKA), which can influence numerous cellular processes including protein glycosylation, indirectly enhancing the functional activity of POMT2. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate inhibits protein tyrosine phosphatases, potentially affecting the phosphorylation status of proteins involved in glycosylation, and could indirectly enhance the functional activity of POMT2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a potent inhibitor of GSK3, a kinase that can affect numerous cellular processes including protein glycosylation, hence potentially enhancing the functional activity of POMT2. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, a key site for protein glycosylation. This disruption can affect glycosylation pathways and indirectly enhance the functional activity of POMT2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium Ionophore A23187 increases intracellular calcium levels affecting various cell signaling pathways, which could potentially influence protein glycosylation processes and indirectly enhance the functional activity of POMT2. | ||||||