POLR3GL Inhibitors
POLR3GL inhibitors are a class of chemical compounds that selectively target and inhibit the function of the POLR3GL protein. POLR3GL is a subunit of RNA polymerase III (Pol III), an essential enzyme complex responsible for synthesizing small, non-coding RNAs such as tRNAs and 5S rRNAs. These molecules are critical for various cellular processes, including the translation of genetic information into functional proteins. POLR3GL is believed to play a regulatory role in modulating the activity of RNA polymerase III, and inhibiting its function can result in the disruption of RNA biosynthesis. The specificity of these inhibitors for POLR3GL enables a more targeted modulation of Pol III activity, which could provide insight into the precise roles of this subunit within the broader enzyme complex.
Chemically, POLR3GL inhibitors vary in their structure, but they typically possess molecular frameworks that enable them to interact with the POLR3GL subunit, either by direct binding or by interfering with the assembly of the Pol III complex. These interactions can affect the stability of the complex or its ability to properly initiate and elongate RNA transcripts. The study of these inhibitors offers significant insights into the structural and functional dynamics of RNA polymerase III, as well as the regulatory mechanisms that control RNA synthesis at the cellular level. Research into POLR3GL inhibitors also enhances our understanding of how modulation of specific subunits in multi-protein complexes like RNA polymerase III can influence global gene expression patterns and cellular homeostasis, opening avenues for exploring fundamental biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-Amanitin inhibits DNA-directed RNA polymerase III subunit C by tightly binding to the enzyme and preventing the elongation phase of RNA transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits DNA-directed RNA polymerase III subunit C by preventing the movement of the polymerase along the DNA template. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DrB inhibits DNA-directed RNA polymerase III subunit C by interfering with the initiation step of RNA synthesis and disrupting the formation of active transcription complexes. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits DNA-directed RNA polymerase III subunit C by covalently modifying the enzyme, leading to the inhibition of RNA synthesis. | ||||||
Tolfenamic Acid | 13710-19-5 | sc-204918 sc-204918A | 5 g 25 g | $69.00 $312.00 | ||
Tolfenamic Acid inhibits DNA-directed RNA polymerase III subunit C by binding to the enzyme and altering its conformation, which in turn inhibits RNA chain elongation. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $462.00 | 6 | |
Beta-Sarcin inhibits DNA-directed RNA polymerase III subunit C by cleaving the phosphodiester bonds in the RNA backbone, leading to the degradation of nascent RNA transcripts. | ||||||
Bufalin | 465-21-4 | sc-200136 sc-200136A sc-200136B sc-200136C | 10 mg 25 mg 50 mg 100 mg | $99.00 $204.00 $341.00 $544.00 | 5 | |
Bufalin inhibits DNA-directed RNA polymerase III subunit C through indirect mechanisms by modulating cellular signaling pathways that are crucial for the proper assembly and function of the polymerase complex. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
ICRF-193 inhibits DNA-directed RNA polymerase III subunit C by binding to topoisomerase II, an enzyme responsible for relieving DNA supercoils during transcription, thereby inhibiting the ability of the polymerase to effectively transcribe DNA. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 inhibits DNA-directed RNA polymerase III subunit C by binding to G-quadruplex structures in rDNA, thereby preventing the proper assembly of transcription machinery at the rDNA promoter. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21 inhibits DNA-directed RNA polymerase III subunit C by binding to RNA polymerase I and disrupting its activity, which indirectly impacts RNA polymerase III due to the shared need for transcriptional resources and regulatory mechanisms. | ||||||